Association study of folate-related enzymes (MTHFR, MTR, MTRR) genetic variants with non-obstructive male infertility in a Polish population

Spermatogenesis is a process where an important contribution of genes involved in folate-mediated one-carbon metabolism is observed. The aim of the present study was to investigate the association between male infertility and the MTHFR (677C > T; 1298A > C), MTR (2756A > G) and MTRR (66A &g...

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Autores principales: Kurzawski, Mateusz, Wajda, Anna, Malinowski, Damian, Kazienko, Anna, Kurzawa, Rafal, Drozdzik, Marek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Genética 2015
Materias:
Human and Medical Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415567/
https://www.ncbi.nlm.nih.gov/pubmed/25983623
http://dx.doi.org/10.1590/S1415-475738120140179
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author Kurzawski, Mateusz
Wajda, Anna
Malinowski, Damian
Kazienko, Anna
Kurzawa, Rafal
Drozdzik, Marek
author_facet Kurzawski, Mateusz
Wajda, Anna
Malinowski, Damian
Kazienko, Anna
Kurzawa, Rafal
Drozdzik, Marek
author_sort Kurzawski, Mateusz
collection PubMed
description Spermatogenesis is a process where an important contribution of genes involved in folate-mediated one-carbon metabolism is observed. The aim of the present study was to investigate the association between male infertility and the MTHFR (677C > T; 1298A > C), MTR (2756A > G) and MTRR (66A > G) polymorphisms in a Polish population. No significant differences in genotype or allele frequencies were detected between the groups of 284 infertile men and of 352 fertile controls. These results demonstrate that common polymorphisms in folate pathway genes are not major risk factors for non-obstructive male infertility in the Polish population.
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spelling pubmed-44155672015-05-15 Association study of folate-related enzymes (MTHFR, MTR, MTRR) genetic variants with non-obstructive male infertility in a Polish population Kurzawski, Mateusz Wajda, Anna Malinowski, Damian Kazienko, Anna Kurzawa, Rafal Drozdzik, Marek Genet Mol Biol Human and Medical Genetics Spermatogenesis is a process where an important contribution of genes involved in folate-mediated one-carbon metabolism is observed. The aim of the present study was to investigate the association between male infertility and the MTHFR (677C > T; 1298A > C), MTR (2756A > G) and MTRR (66A > G) polymorphisms in a Polish population. No significant differences in genotype or allele frequencies were detected between the groups of 284 infertile men and of 352 fertile controls. These results demonstrate that common polymorphisms in folate pathway genes are not major risk factors for non-obstructive male infertility in the Polish population. Sociedade Brasileira de Genética 2015-03 2014-03-17 /pmc/articles/PMC4415567/ /pubmed/25983623 http://dx.doi.org/10.1590/S1415-475738120140179 Text en Copyright © 2015, Sociedade Brasileira de Genética. http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Human and Medical Genetics
Kurzawski, Mateusz
Wajda, Anna
Malinowski, Damian
Kazienko, Anna
Kurzawa, Rafal
Drozdzik, Marek
Association study of folate-related enzymes (MTHFR, MTR, MTRR) genetic variants with non-obstructive male infertility in a Polish population
title Association study of folate-related enzymes (MTHFR, MTR, MTRR) genetic variants with non-obstructive male infertility in a Polish population
title_full Association study of folate-related enzymes (MTHFR, MTR, MTRR) genetic variants with non-obstructive male infertility in a Polish population
title_fullStr Association study of folate-related enzymes (MTHFR, MTR, MTRR) genetic variants with non-obstructive male infertility in a Polish population
title_full_unstemmed Association study of folate-related enzymes (MTHFR, MTR, MTRR) genetic variants with non-obstructive male infertility in a Polish population
title_short Association study of folate-related enzymes (MTHFR, MTR, MTRR) genetic variants with non-obstructive male infertility in a Polish population
title_sort association study of folate-related enzymes (mthfr, mtr, mtrr) genetic variants with non-obstructive male infertility in a polish population
topic Human and Medical Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415567/
https://www.ncbi.nlm.nih.gov/pubmed/25983623
http://dx.doi.org/10.1590/S1415-475738120140179
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