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Capacity Planning for Batch and Perfusion Bioprocesses Across Multiple Biopharmaceutical Facilities

Production planning for biopharmaceutical portfolios becomes more complex when products switch between fed-batch and continuous perfusion culture processes. This article describes the development of a discrete-time mixed integer linear programming (MILP) model to optimize capacity plans for multiple...

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Detalles Bibliográficos
Autores principales:	Siganporia, Cyrus C, Ghosh, Soumitra, Daszkowski, Thomas, Papageorgiou, Lazaros G, Farid, Suzanne S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2014
Materias:	Special Section: Cho-Based Biomanufacturing and Antibody Products
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415584/ https://www.ncbi.nlm.nih.gov/pubmed/24376262 http://dx.doi.org/10.1002/btpr.1860

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