Roles of Solvent Accessibility and Gene Expression in Modeling Protein Sequence Evolution

Models of protein evolution tend to ignore functional constraints, although structural constraints are sometimes incorporated. Here we propose a probabilistic framework for codon substitution that evaluates joint effects of relative solvent accessibility (RSA), a structural constraint; and gene expr...

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Detalles Bibliográficos
Autores principales: Wang, Kuangyu, Yu, Shuhui, Ji, Xiang, Lakner, Clemens, Griffing, Alexander, Thorne, Jeffrey L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Libertas Academica 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415675/
https://www.ncbi.nlm.nih.gov/pubmed/25987828
http://dx.doi.org/10.4137/EBO.S22911

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