Agaricoglycerides Protect against Hepatic Ischemia/Reperfusion Injury by Attenuating Inflammatory Response, Oxidative Stress, and Expression of NF-κB

We have investigated the effects of agaricoglycerides (AG) in a mouse model of hepatic I/R injury. I/R triggered increases/changes in markers of liver injury, hepatic oxidative stress, tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and nuclear factor κB (NF-κB). AG significantly reduced th...

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Detalles Bibliográficos
Autores principales: Zhao, Xiang-qian, Liang, Bin, Liu, Yang, Huang, Xiao-qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415680/
https://www.ncbi.nlm.nih.gov/pubmed/25960746
http://dx.doi.org/10.1155/2015/142736
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author Zhao, Xiang-qian
Liang, Bin
Liu, Yang
Huang, Xiao-qiang
author_facet Zhao, Xiang-qian
Liang, Bin
Liu, Yang
Huang, Xiao-qiang
author_sort Zhao, Xiang-qian
collection PubMed
description We have investigated the effects of agaricoglycerides (AG) in a mouse model of hepatic I/R injury. I/R triggered increases/changes in markers of liver injury, hepatic oxidative stress, tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and nuclear factor κB (NF-κB). AG significantly reduced the extent of liver inflammation and oxidative stress and also attenuated the NF-κB activation as well as TNF-α and IL-1β production. Our results indicate that AG may represent a novel protective strategy against I/R-induced injury and inflammatory diseases.
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spelling pubmed-44156802015-05-10 Agaricoglycerides Protect against Hepatic Ischemia/Reperfusion Injury by Attenuating Inflammatory Response, Oxidative Stress, and Expression of NF-κB Zhao, Xiang-qian Liang, Bin Liu, Yang Huang, Xiao-qiang Evid Based Complement Alternat Med Research Article We have investigated the effects of agaricoglycerides (AG) in a mouse model of hepatic I/R injury. I/R triggered increases/changes in markers of liver injury, hepatic oxidative stress, tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and nuclear factor κB (NF-κB). AG significantly reduced the extent of liver inflammation and oxidative stress and also attenuated the NF-κB activation as well as TNF-α and IL-1β production. Our results indicate that AG may represent a novel protective strategy against I/R-induced injury and inflammatory diseases. Hindawi Publishing Corporation 2015 2015-04-16 /pmc/articles/PMC4415680/ /pubmed/25960746 http://dx.doi.org/10.1155/2015/142736 Text en Copyright © 2015 Xiang-qian Zhao et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zhao, Xiang-qian
Liang, Bin
Liu, Yang
Huang, Xiao-qiang
Agaricoglycerides Protect against Hepatic Ischemia/Reperfusion Injury by Attenuating Inflammatory Response, Oxidative Stress, and Expression of NF-κB
title Agaricoglycerides Protect against Hepatic Ischemia/Reperfusion Injury by Attenuating Inflammatory Response, Oxidative Stress, and Expression of NF-κB
title_full Agaricoglycerides Protect against Hepatic Ischemia/Reperfusion Injury by Attenuating Inflammatory Response, Oxidative Stress, and Expression of NF-κB
title_fullStr Agaricoglycerides Protect against Hepatic Ischemia/Reperfusion Injury by Attenuating Inflammatory Response, Oxidative Stress, and Expression of NF-κB
title_full_unstemmed Agaricoglycerides Protect against Hepatic Ischemia/Reperfusion Injury by Attenuating Inflammatory Response, Oxidative Stress, and Expression of NF-κB
title_short Agaricoglycerides Protect against Hepatic Ischemia/Reperfusion Injury by Attenuating Inflammatory Response, Oxidative Stress, and Expression of NF-κB
title_sort agaricoglycerides protect against hepatic ischemia/reperfusion injury by attenuating inflammatory response, oxidative stress, and expression of nf-κb
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415680/
https://www.ncbi.nlm.nih.gov/pubmed/25960746
http://dx.doi.org/10.1155/2015/142736
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