A Novobiocin Derivative, XN4, Inhibits the Proliferation of Chronic Myeloid Leukemia Cells by Inducing Oxidative DNA Damage

XN4 might induce DNA damage and apoptotic cell death through reactive oxygen species (ROS). The inhibition of proliferation of K562 and K562/G01 cells was measured by MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide). The mRNA levels of NADPH oxidase 1-5 (Nox1-5) genes were evaluate...

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Detalles Bibliográficos
Autores principales: Wu, Lixian, Chen, Xianling, Huang, Lisen, Tian, Jue, Ke, Fang, Xu, Jianhua, Chen, Yuanzhong, Zheng, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415758/
https://www.ncbi.nlm.nih.gov/pubmed/25928540
http://dx.doi.org/10.1371/journal.pone.0123314

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415758/
https://www.ncbi.nlm.nih.gov/pubmed/25928540
http://dx.doi.org/10.1371/journal.pone.0123314

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