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Personalized Biochemistry and Biophysics

[Image: see text] Whole human genome sequencing of individuals is becoming rapid and inexpensive, enabling new strategies for using personal genome information to help diagnose, treat, and even prevent human disorders for which genetic variations are causative or are known to be risk factors. Many o...

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Autores principales: Kroncke, Brett M., Vanoye, Carlos G., Meiler, Jens, George, Alfred L., Sanders, Charles R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2015
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415889/
https://www.ncbi.nlm.nih.gov/pubmed/25856502
http://dx.doi.org/10.1021/acs.biochem.5b00189
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author Kroncke, Brett M.
Vanoye, Carlos G.
Meiler, Jens
George, Alfred L.
Sanders, Charles R.
author_facet Kroncke, Brett M.
Vanoye, Carlos G.
Meiler, Jens
George, Alfred L.
Sanders, Charles R.
author_sort Kroncke, Brett M.
collection PubMed
description [Image: see text] Whole human genome sequencing of individuals is becoming rapid and inexpensive, enabling new strategies for using personal genome information to help diagnose, treat, and even prevent human disorders for which genetic variations are causative or are known to be risk factors. Many of the exploding number of newly discovered genetic variations alter the structure, function, dynamics, stability, and/or interactions of specific proteins and RNA molecules. Accordingly, there are a host of opportunities for biochemists and biophysicists to participate in (1) developing tools to allow accurate and sometimes medically actionable assessment of the potential pathogenicity of individual variations and (2) establishing the mechanistic linkage between pathogenic variations and their physiological consequences, providing a rational basis for treatment or preventive care. In this review, we provide an overview of these opportunities and their associated challenges in light of the current status of genomic science and personalized medicine, the latter often termed precision medicine.
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spelling pubmed-44158892016-04-09 Personalized Biochemistry and Biophysics Kroncke, Brett M. Vanoye, Carlos G. Meiler, Jens George, Alfred L. Sanders, Charles R. Biochemistry [Image: see text] Whole human genome sequencing of individuals is becoming rapid and inexpensive, enabling new strategies for using personal genome information to help diagnose, treat, and even prevent human disorders for which genetic variations are causative or are known to be risk factors. Many of the exploding number of newly discovered genetic variations alter the structure, function, dynamics, stability, and/or interactions of specific proteins and RNA molecules. Accordingly, there are a host of opportunities for biochemists and biophysicists to participate in (1) developing tools to allow accurate and sometimes medically actionable assessment of the potential pathogenicity of individual variations and (2) establishing the mechanistic linkage between pathogenic variations and their physiological consequences, providing a rational basis for treatment or preventive care. In this review, we provide an overview of these opportunities and their associated challenges in light of the current status of genomic science and personalized medicine, the latter often termed precision medicine. American Chemical Society 2015-04-09 2015-04-28 /pmc/articles/PMC4415889/ /pubmed/25856502 http://dx.doi.org/10.1021/acs.biochem.5b00189 Text en Copyright © 2015 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Kroncke, Brett M.
Vanoye, Carlos G.
Meiler, Jens
George, Alfred L.
Sanders, Charles R.
Personalized Biochemistry and Biophysics
title Personalized Biochemistry and Biophysics
title_full Personalized Biochemistry and Biophysics
title_fullStr Personalized Biochemistry and Biophysics
title_full_unstemmed Personalized Biochemistry and Biophysics
title_short Personalized Biochemistry and Biophysics
title_sort personalized biochemistry and biophysics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415889/
https://www.ncbi.nlm.nih.gov/pubmed/25856502
http://dx.doi.org/10.1021/acs.biochem.5b00189
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