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Oligomerization of Cu,Zn-Superoxide Dismutase (SOD1) by Docosahexaenoic Acid and Its Hydroperoxides In Vitro: Aggregation Dependence on Fatty Acid Unsaturation and Thiols

Docosahexaenoic acid (C22:6, n-3, DHA) is a polyunsaturated fatty acid highly enriched in the brain. This fatty acid can be easily oxidized yielding hydroperoxides as primary products. Cu, Zn-Superoxide dismutase (SOD1) aggregation is a common hallmark of Amyotrophic Lateral Sclerosis (ALS) and the...

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Detalles Bibliográficos
Autores principales:	Appolinário, Patricia Postilione, Medinas, Danilo Bilches, Chaves-Filho, Adriano B., Genaro-Mattos, Thiago C., Cussiol, José Renato Rosa, Netto, Luis Eduardo Soares, Augusto, Ohara, Miyamoto, Sayuri
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415921/ https://www.ncbi.nlm.nih.gov/pubmed/25928076 http://dx.doi.org/10.1371/journal.pone.0125146

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