Effects of oxidized and reduced forms of methylthioninium in two transgenic mouse tauopathy models

Given the repeated failure of amyloid-based approaches in Alzheimer’s disease, there is increasing interest in tau-based therapeutics. Although methylthioninium (MT) treatment was found to be beneficial in tau transgenic models, the brain concentrations required to inhibit tau aggregation in vivo ar...

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Detalles Bibliográficos
Autores principales: Melis, Valeria, Magbagbeolu, Mandy, Rickard, Janet E., Horsley, David, Davidson, Kathleen, Harrington, Kathleen A., Goatman, Keith, Goatman, Elizabeth A., Deiana, Serena, Close, Steve P., Zabke, Claudia, Stamer, Karsten, Dietze, Silke, Schwab, Karima, Storey, John M.D., Harrington, Charles R., Wischik, Claude M., Theuring, Franz, Riedel, Gernot
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams and Wilkins 2015
Materias:
Research Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416029/
https://www.ncbi.nlm.nih.gov/pubmed/25769090
http://dx.doi.org/10.1097/FBP.0000000000000133

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