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Distinct Developmental Origins Manifest in the Specialized Encoding of Movement by Adult Neurons of the External Globus Pallidus

Transcriptional codes initiated during brain development are ultimately realized in adulthood as distinct cell types performing specialized roles in behavior. Focusing on the mouse external globus pallidus (GPe), we demonstrate that the potential contributions of two GABAergic GPe cell types to volu...

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Autores principales: Dodson, Paul D., Larvin, Joseph T., Duffell, James M., Garas, Farid N., Doig, Natalie M., Kessaris, Nicoletta, Duguid, Ian C., Bogacz, Rafal, Butt, Simon J.B., Magill, Peter J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416107/
https://www.ncbi.nlm.nih.gov/pubmed/25843402
http://dx.doi.org/10.1016/j.neuron.2015.03.007
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author Dodson, Paul D.
Larvin, Joseph T.
Duffell, James M.
Garas, Farid N.
Doig, Natalie M.
Kessaris, Nicoletta
Duguid, Ian C.
Bogacz, Rafal
Butt, Simon J.B.
Magill, Peter J.
author_facet Dodson, Paul D.
Larvin, Joseph T.
Duffell, James M.
Garas, Farid N.
Doig, Natalie M.
Kessaris, Nicoletta
Duguid, Ian C.
Bogacz, Rafal
Butt, Simon J.B.
Magill, Peter J.
author_sort Dodson, Paul D.
collection PubMed
description Transcriptional codes initiated during brain development are ultimately realized in adulthood as distinct cell types performing specialized roles in behavior. Focusing on the mouse external globus pallidus (GPe), we demonstrate that the potential contributions of two GABAergic GPe cell types to voluntary action are fated from early life to be distinct. Prototypic GPe neurons derive from the medial ganglionic eminence of the embryonic subpallium and express the transcription factor Nkx2-1. These neurons fire at high rates during alert rest, and encode movements through heterogeneous firing rate changes, with many neurons decreasing their activity. In contrast, arkypallidal GPe neurons originate from lateral/caudal ganglionic eminences, express the transcription factor FoxP2, fire at low rates during rest, and encode movements with robust increases in firing. We conclude that developmental diversity positions prototypic and arkypallidal neurons to fulfil distinct roles in behavior via their disparate regulation of GABA release onto different basal ganglia targets.
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spelling pubmed-44161072015-05-04 Distinct Developmental Origins Manifest in the Specialized Encoding of Movement by Adult Neurons of the External Globus Pallidus Dodson, Paul D. Larvin, Joseph T. Duffell, James M. Garas, Farid N. Doig, Natalie M. Kessaris, Nicoletta Duguid, Ian C. Bogacz, Rafal Butt, Simon J.B. Magill, Peter J. Neuron Article Transcriptional codes initiated during brain development are ultimately realized in adulthood as distinct cell types performing specialized roles in behavior. Focusing on the mouse external globus pallidus (GPe), we demonstrate that the potential contributions of two GABAergic GPe cell types to voluntary action are fated from early life to be distinct. Prototypic GPe neurons derive from the medial ganglionic eminence of the embryonic subpallium and express the transcription factor Nkx2-1. These neurons fire at high rates during alert rest, and encode movements through heterogeneous firing rate changes, with many neurons decreasing their activity. In contrast, arkypallidal GPe neurons originate from lateral/caudal ganglionic eminences, express the transcription factor FoxP2, fire at low rates during rest, and encode movements with robust increases in firing. We conclude that developmental diversity positions prototypic and arkypallidal neurons to fulfil distinct roles in behavior via their disparate regulation of GABA release onto different basal ganglia targets. Cell Press 2015-04-22 /pmc/articles/PMC4416107/ /pubmed/25843402 http://dx.doi.org/10.1016/j.neuron.2015.03.007 Text en © 2015 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Dodson, Paul D.
Larvin, Joseph T.
Duffell, James M.
Garas, Farid N.
Doig, Natalie M.
Kessaris, Nicoletta
Duguid, Ian C.
Bogacz, Rafal
Butt, Simon J.B.
Magill, Peter J.
Distinct Developmental Origins Manifest in the Specialized Encoding of Movement by Adult Neurons of the External Globus Pallidus
title Distinct Developmental Origins Manifest in the Specialized Encoding of Movement by Adult Neurons of the External Globus Pallidus
title_full Distinct Developmental Origins Manifest in the Specialized Encoding of Movement by Adult Neurons of the External Globus Pallidus
title_fullStr Distinct Developmental Origins Manifest in the Specialized Encoding of Movement by Adult Neurons of the External Globus Pallidus
title_full_unstemmed Distinct Developmental Origins Manifest in the Specialized Encoding of Movement by Adult Neurons of the External Globus Pallidus
title_short Distinct Developmental Origins Manifest in the Specialized Encoding of Movement by Adult Neurons of the External Globus Pallidus
title_sort distinct developmental origins manifest in the specialized encoding of movement by adult neurons of the external globus pallidus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416107/
https://www.ncbi.nlm.nih.gov/pubmed/25843402
http://dx.doi.org/10.1016/j.neuron.2015.03.007
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