Elastin fragmentation in atherosclerotic mice leads to intraplaque neovascularization, plaque rupture, myocardial infarction, stroke, and sudden death

AIMS: There is a need for animal models of plaque rupture. We previously reported that elastin fragmentation, due to a mutation (C1039G(+/−)) in the fibrillin-1 (Fbn1) gene, promotes atherogenesis and a highly unstable plaque phenotype in apolipoprotein E deficient (ApoE(−/−)) mice on a Western-type...

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Detalles Bibliográficos
Autores principales: Van der Donckt, Carole, Van Herck, Jozef L., Schrijvers, Dorien M., Vanhoutte, Greetje, Verhoye, Marleen, Blockx, Ines, Van Der Linden, Annemie, Bauters, Dries, Lijnen, Henri R., Sluimer, Judith C., Roth, Lynn, Van Hove, Cor E., Fransen, Paul, Knaapen, Michiel W., Hervent, Anne-Sophie, De Keulenaer, Gilles W., Bult, Hidde, Martinet, Wim, Herman, Arnold G., De Meyer, Guido R.Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Basic Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416138/
https://www.ncbi.nlm.nih.gov/pubmed/24553721
http://dx.doi.org/10.1093/eurheartj/ehu041

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416138/
https://www.ncbi.nlm.nih.gov/pubmed/24553721
http://dx.doi.org/10.1093/eurheartj/ehu041

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