Discovery of a Small-Molecule Probe for V-ATPase Function

[Image: see text] Lysosomes perform a critical cellular function as a site of degradation for diverse cargoes including proteins, organelles, and pathogens delivered through distinct pathways, and defects in lysosomal function have been implicated in a number of diseases. Recent studies have elucida...

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Autores principales: Aldrich, Leslie N., Kuo, Szu-Yu, Castoreno, Adam B., Goel, Gautam, Kuballa, Petric, Rees, Matthew G., Seashore-Ludlow, Brinton A., Cheah, Jaime H., Latorre, Isabel J., Schreiber, Stuart L., Shamji, Alykhan F., Xavier, Ramnik J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2015
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416280/
https://www.ncbi.nlm.nih.gov/pubmed/25860544
http://dx.doi.org/10.1021/jacs.5b02150
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author Aldrich, Leslie N.
Kuo, Szu-Yu
Castoreno, Adam B.
Goel, Gautam
Kuballa, Petric
Rees, Matthew G.
Seashore-Ludlow, Brinton A.
Cheah, Jaime H.
Latorre, Isabel J.
Schreiber, Stuart L.
Shamji, Alykhan F.
Xavier, Ramnik J.
author_facet Aldrich, Leslie N.
Kuo, Szu-Yu
Castoreno, Adam B.
Goel, Gautam
Kuballa, Petric
Rees, Matthew G.
Seashore-Ludlow, Brinton A.
Cheah, Jaime H.
Latorre, Isabel J.
Schreiber, Stuart L.
Shamji, Alykhan F.
Xavier, Ramnik J.
author_sort Aldrich, Leslie N.
collection PubMed
description [Image: see text] Lysosomes perform a critical cellular function as a site of degradation for diverse cargoes including proteins, organelles, and pathogens delivered through distinct pathways, and defects in lysosomal function have been implicated in a number of diseases. Recent studies have elucidated roles for the lysosome in the regulation of protein synthesis, metabolism, membrane integrity, and other processes involved in homeostasis. Complex small-molecule natural products have greatly contributed to the investigation of lysosomal function in cellular physiology. Here we report the discovery of a novel, small-molecule modulator of lysosomal acidification derived from diversity-oriented synthesis through high-content screening.
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spelling pubmed-44162802015-05-04 Discovery of a Small-Molecule Probe for V-ATPase Function Aldrich, Leslie N. Kuo, Szu-Yu Castoreno, Adam B. Goel, Gautam Kuballa, Petric Rees, Matthew G. Seashore-Ludlow, Brinton A. Cheah, Jaime H. Latorre, Isabel J. Schreiber, Stuart L. Shamji, Alykhan F. Xavier, Ramnik J. J Am Chem Soc [Image: see text] Lysosomes perform a critical cellular function as a site of degradation for diverse cargoes including proteins, organelles, and pathogens delivered through distinct pathways, and defects in lysosomal function have been implicated in a number of diseases. Recent studies have elucidated roles for the lysosome in the regulation of protein synthesis, metabolism, membrane integrity, and other processes involved in homeostasis. Complex small-molecule natural products have greatly contributed to the investigation of lysosomal function in cellular physiology. Here we report the discovery of a novel, small-molecule modulator of lysosomal acidification derived from diversity-oriented synthesis through high-content screening. American Chemical Society 2015-04-10 2015-04-29 /pmc/articles/PMC4416280/ /pubmed/25860544 http://dx.doi.org/10.1021/jacs.5b02150 Text en Copyright © 2015 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Aldrich, Leslie N.
Kuo, Szu-Yu
Castoreno, Adam B.
Goel, Gautam
Kuballa, Petric
Rees, Matthew G.
Seashore-Ludlow, Brinton A.
Cheah, Jaime H.
Latorre, Isabel J.
Schreiber, Stuart L.
Shamji, Alykhan F.
Xavier, Ramnik J.
Discovery of a Small-Molecule Probe for V-ATPase Function
title Discovery of a Small-Molecule Probe for V-ATPase Function
title_full Discovery of a Small-Molecule Probe for V-ATPase Function
title_fullStr Discovery of a Small-Molecule Probe for V-ATPase Function
title_full_unstemmed Discovery of a Small-Molecule Probe for V-ATPase Function
title_short Discovery of a Small-Molecule Probe for V-ATPase Function
title_sort discovery of a small-molecule probe for v-atpase function
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416280/
https://www.ncbi.nlm.nih.gov/pubmed/25860544
http://dx.doi.org/10.1021/jacs.5b02150
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