Germline MUTYH gene mutations are not frequently found in unselected patients with papillary breast carcinoma

MUTYH-associated polyposis (MAP) is an autosomal recessive disease, which predisposes to polyposis and colorectal cancer. There is a trend towards an increased risk of breast cancer in MAP patients, with a remarkable proportion of papillary breast cancers. To determine whether MUTYH mutations are as...

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Autores principales: Boesaard, Ewout P, Vogelaar, Ingrid P, Bult, Peter, Wauters, Carla AP, van Krieken, J Han JM, Ligtenberg, Marjolijn JL, van der Post, Rachel S, Hoogerbrugge, Nicoline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416291/
https://www.ncbi.nlm.nih.gov/pubmed/25937855
http://dx.doi.org/10.1186/1897-4287-12-21
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author Boesaard, Ewout P
Vogelaar, Ingrid P
Bult, Peter
Wauters, Carla AP
van Krieken, J Han JM
Ligtenberg, Marjolijn JL
van der Post, Rachel S
Hoogerbrugge, Nicoline
author_facet Boesaard, Ewout P
Vogelaar, Ingrid P
Bult, Peter
Wauters, Carla AP
van Krieken, J Han JM
Ligtenberg, Marjolijn JL
van der Post, Rachel S
Hoogerbrugge, Nicoline
author_sort Boesaard, Ewout P
collection PubMed
description MUTYH-associated polyposis (MAP) is an autosomal recessive disease, which predisposes to polyposis and colorectal cancer. There is a trend towards an increased risk of breast cancer in MAP patients, with a remarkable proportion of papillary breast cancers. To determine whether MUTYH mutations are associated with this specific and rare type of breast cancer, 53 unselected patients with papillary breast cancer were analyzed for founder mutations in the MUTYH gene. No germline mutations were identified, indicating that biallelic MUTYH mutations are not a frequent underlying cause for the development of papillary carcinomas of the breast.
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spelling pubmed-44162912015-05-02 Germline MUTYH gene mutations are not frequently found in unselected patients with papillary breast carcinoma Boesaard, Ewout P Vogelaar, Ingrid P Bult, Peter Wauters, Carla AP van Krieken, J Han JM Ligtenberg, Marjolijn JL van der Post, Rachel S Hoogerbrugge, Nicoline Hered Cancer Clin Pract Research MUTYH-associated polyposis (MAP) is an autosomal recessive disease, which predisposes to polyposis and colorectal cancer. There is a trend towards an increased risk of breast cancer in MAP patients, with a remarkable proportion of papillary breast cancers. To determine whether MUTYH mutations are associated with this specific and rare type of breast cancer, 53 unselected patients with papillary breast cancer were analyzed for founder mutations in the MUTYH gene. No germline mutations were identified, indicating that biallelic MUTYH mutations are not a frequent underlying cause for the development of papillary carcinomas of the breast. BioMed Central 2014-12-12 /pmc/articles/PMC4416291/ /pubmed/25937855 http://dx.doi.org/10.1186/1897-4287-12-21 Text en © Boesaard et al.; licensee BioMed Central. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Boesaard, Ewout P
Vogelaar, Ingrid P
Bult, Peter
Wauters, Carla AP
van Krieken, J Han JM
Ligtenberg, Marjolijn JL
van der Post, Rachel S
Hoogerbrugge, Nicoline
Germline MUTYH gene mutations are not frequently found in unselected patients with papillary breast carcinoma
title Germline MUTYH gene mutations are not frequently found in unselected patients with papillary breast carcinoma
title_full Germline MUTYH gene mutations are not frequently found in unselected patients with papillary breast carcinoma
title_fullStr Germline MUTYH gene mutations are not frequently found in unselected patients with papillary breast carcinoma
title_full_unstemmed Germline MUTYH gene mutations are not frequently found in unselected patients with papillary breast carcinoma
title_short Germline MUTYH gene mutations are not frequently found in unselected patients with papillary breast carcinoma
title_sort germline mutyh gene mutations are not frequently found in unselected patients with papillary breast carcinoma
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416291/
https://www.ncbi.nlm.nih.gov/pubmed/25937855
http://dx.doi.org/10.1186/1897-4287-12-21
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