Ubiquitin-SUMO Circuitry Controls Activated Fanconi Anemia ID Complex Dosage in Response to DNA Damage

We show that central components of the Fanconi anemia (FA) DNA repair pathway, the tumor suppressor proteins FANCI and FANCD2 (the ID complex), are SUMOylated in response to replication fork stalling. The ID complex is SUMOylated in a manner that depends on the ATR kinase, the FA ubiquitin ligase co...

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Detalles Bibliográficos
Autores principales: Gibbs-Seymour, Ian, Oka, Yasuyoshi, Rajendra, Eeson, Weinert, Brian T., Passmore, Lori A., Patel, Ketan J., Olsen, Jesper V., Choudhary, Chunaram, Bekker-Jensen, Simon, Mailand, Niels
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416315/
https://www.ncbi.nlm.nih.gov/pubmed/25557546
http://dx.doi.org/10.1016/j.molcel.2014.12.001

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