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Population pharmacokinetic and pharmacodynamic modeling of transformed binary effect data of triflusal in healthy Korean male volunteers: a randomized, open-label, multiple dose, crossover study

BACKGROUND: Triflusal is a drug that inhibits platelet aggregation. In this study we investigated the dose-exposure-response relationship of a triflusal formulation by population pharmacokinetic (PK) and pharmacodynamic (PD) modeling of its main active metabolite, hydroxy-4-(trifluoromethyl) benzoic...

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Detalles Bibliográficos
Autores principales:	Park, Sung Min, Lee, Joomi, Seong, Sook Jin, Park, Jong Gwang, Gwon, Mi-Ri, Lim, Mi-sun, Lee, Hae Won, Yoon, Young-Ran, Yang, Dong Heon, Kwon, Kwang-Il, Han, Seunghoon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416384/ https://www.ncbi.nlm.nih.gov/pubmed/25534747 http://dx.doi.org/10.1186/2050-6511-15-75

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