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Persistence of a hyperthermic sign-reversal during nitrous oxide inhalation despite cue-exposure treatment with and without a drug-onset cue

We asked whether chronic tolerance and the hyperthermic sign-reversal induced by repeated 60% N(2)O exposures could be extinguished using a cue-exposure paradigm. Rats received 18 N(2)O administrations in a total calorimetry system that simultaneously measures core temperature (Tc), metabolic heat p...

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Autores principales: Kaiyala, Karl J, Woods, Stephen C, Ramsay, Douglas S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416485/
https://www.ncbi.nlm.nih.gov/pubmed/25938128
http://dx.doi.org/10.4161/23328940.2014.944811
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author Kaiyala, Karl J
Woods, Stephen C
Ramsay, Douglas S
author_facet Kaiyala, Karl J
Woods, Stephen C
Ramsay, Douglas S
author_sort Kaiyala, Karl J
collection PubMed
description We asked whether chronic tolerance and the hyperthermic sign-reversal induced by repeated 60% N(2)O exposures could be extinguished using a cue-exposure paradigm. Rats received 18 N(2)O administrations in a total calorimetry system that simultaneously measures core temperature (Tc), metabolic heat production (HP), and body heat loss (HL). Each exposure entailed a 2-h baseline period followed by a 1.5-h N(2)O exposure. The 18 drug exposures induced a robust intra-administration hyperthermia in which the initial hypothermic effect of N(2)O inverted to a significant hyperthermic sign-reversal during N(2)O inhalation due primarily to an acquired robust increase in HP. The rats were then randomized to one of 3 extinction procedures (n = 8/procedure) over a 20-d interval: 1) a N(2)O-abstinent home-cage group (HC) that received only the usual animal care; 2) a cue-exposure group (CEXP) in which the animals were placed in the calorimeter 8 times but received no N(2)O; and 3) a drug-onset-cue group (DOC) in which animals received a brief N(2)O exposure in the calorimeter that mimicked the first 3 min of an actual 60% N(2)O trial. Following the extinction sessions, all rats received a 60% N(2)O test trial and Tc, HP and HL were assessed. The hyperthermic sign-reversal remained fully intact during the test trial, with no significant differences observed among groups in any post-baseline change in any thermal outcome. These data suggest that cue exposure may not be an efficacious strategy to reduce sign-reversals that develop with chronic drug use.
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spelling pubmed-44164852015-05-01 Persistence of a hyperthermic sign-reversal during nitrous oxide inhalation despite cue-exposure treatment with and without a drug-onset cue Kaiyala, Karl J Woods, Stephen C Ramsay, Douglas S Temperature (Austin) Research Paper We asked whether chronic tolerance and the hyperthermic sign-reversal induced by repeated 60% N(2)O exposures could be extinguished using a cue-exposure paradigm. Rats received 18 N(2)O administrations in a total calorimetry system that simultaneously measures core temperature (Tc), metabolic heat production (HP), and body heat loss (HL). Each exposure entailed a 2-h baseline period followed by a 1.5-h N(2)O exposure. The 18 drug exposures induced a robust intra-administration hyperthermia in which the initial hypothermic effect of N(2)O inverted to a significant hyperthermic sign-reversal during N(2)O inhalation due primarily to an acquired robust increase in HP. The rats were then randomized to one of 3 extinction procedures (n = 8/procedure) over a 20-d interval: 1) a N(2)O-abstinent home-cage group (HC) that received only the usual animal care; 2) a cue-exposure group (CEXP) in which the animals were placed in the calorimeter 8 times but received no N(2)O; and 3) a drug-onset-cue group (DOC) in which animals received a brief N(2)O exposure in the calorimeter that mimicked the first 3 min of an actual 60% N(2)O trial. Following the extinction sessions, all rats received a 60% N(2)O test trial and Tc, HP and HL were assessed. The hyperthermic sign-reversal remained fully intact during the test trial, with no significant differences observed among groups in any post-baseline change in any thermal outcome. These data suggest that cue exposure may not be an efficacious strategy to reduce sign-reversals that develop with chronic drug use. Taylor & Francis 2014-10-31 /pmc/articles/PMC4416485/ /pubmed/25938128 http://dx.doi.org/10.4161/23328940.2014.944811 Text en © 2014 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0/, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Research Paper
Kaiyala, Karl J
Woods, Stephen C
Ramsay, Douglas S
Persistence of a hyperthermic sign-reversal during nitrous oxide inhalation despite cue-exposure treatment with and without a drug-onset cue
title Persistence of a hyperthermic sign-reversal during nitrous oxide inhalation despite cue-exposure treatment with and without a drug-onset cue
title_full Persistence of a hyperthermic sign-reversal during nitrous oxide inhalation despite cue-exposure treatment with and without a drug-onset cue
title_fullStr Persistence of a hyperthermic sign-reversal during nitrous oxide inhalation despite cue-exposure treatment with and without a drug-onset cue
title_full_unstemmed Persistence of a hyperthermic sign-reversal during nitrous oxide inhalation despite cue-exposure treatment with and without a drug-onset cue
title_short Persistence of a hyperthermic sign-reversal during nitrous oxide inhalation despite cue-exposure treatment with and without a drug-onset cue
title_sort persistence of a hyperthermic sign-reversal during nitrous oxide inhalation despite cue-exposure treatment with and without a drug-onset cue
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416485/
https://www.ncbi.nlm.nih.gov/pubmed/25938128
http://dx.doi.org/10.4161/23328940.2014.944811
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