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Delineation of a frequency-organized region isolated from the mouse primary auditory cortex
The primary auditory cortex (AI) is the representative recipient of information from the ears in the mammalian cortex. However, the delineation of the AI is still controversial in a mouse. Recently, it was reported, using optical imaging, that two distinct areas of the AI, located ventrally and dors...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Physiological Society
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416634/ https://www.ncbi.nlm.nih.gov/pubmed/25695649 http://dx.doi.org/10.1152/jn.00932.2014 |
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author | Tsukano, Hiroaki Horie, Masao Bo, Takeshi Uchimura, Arikuni Hishida, Ryuichi Kudoh, Masaharu Takahashi, Kuniyuki Takebayashi, Hirohide Shibuki, Katsuei |
author_facet | Tsukano, Hiroaki Horie, Masao Bo, Takeshi Uchimura, Arikuni Hishida, Ryuichi Kudoh, Masaharu Takahashi, Kuniyuki Takebayashi, Hirohide Shibuki, Katsuei |
author_sort | Tsukano, Hiroaki |
collection | PubMed |
description | The primary auditory cortex (AI) is the representative recipient of information from the ears in the mammalian cortex. However, the delineation of the AI is still controversial in a mouse. Recently, it was reported, using optical imaging, that two distinct areas of the AI, located ventrally and dorsally, are activated by high-frequency tones, whereas only one area is activated by low-frequency tones. Here, we show that the dorsal high-frequency area is an independent region that is separated from the rest of the AI. We could visualize the two distinct high-frequency areas using flavoprotein fluorescence imaging, as reported previously. SMI-32 immunolabeling revealed that the dorsal region had a different cytoarchitectural pattern from the rest of the AI. Specifically, the ratio of SMI-32-positive pyramidal neurons to nonpyramidal neurons was larger in the dorsal high-frequency area than the rest of the AI. We named this new region the dorsomedial field (DM). Retrograde tracing showed that neurons projecting to the DM were localized in the rostral part of the ventral division of the medial geniculate body with a distinct frequency organization, where few neurons projected to the AI. Furthermore, the responses of the DM to ultrasonic courtship songs presented by males were significantly greater in females than in males; in contrast, there was no sex difference in response to artificial pure tones. Our findings offer a basic outline on the processing of ultrasonic vocal information on the basis of the precisely subdivided, multiple frequency-organized auditory cortex map in mice. |
format | Online Article Text |
id | pubmed-4416634 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | American Physiological Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-44166342016-04-01 Delineation of a frequency-organized region isolated from the mouse primary auditory cortex Tsukano, Hiroaki Horie, Masao Bo, Takeshi Uchimura, Arikuni Hishida, Ryuichi Kudoh, Masaharu Takahashi, Kuniyuki Takebayashi, Hirohide Shibuki, Katsuei J Neurophysiol Sensory Processing The primary auditory cortex (AI) is the representative recipient of information from the ears in the mammalian cortex. However, the delineation of the AI is still controversial in a mouse. Recently, it was reported, using optical imaging, that two distinct areas of the AI, located ventrally and dorsally, are activated by high-frequency tones, whereas only one area is activated by low-frequency tones. Here, we show that the dorsal high-frequency area is an independent region that is separated from the rest of the AI. We could visualize the two distinct high-frequency areas using flavoprotein fluorescence imaging, as reported previously. SMI-32 immunolabeling revealed that the dorsal region had a different cytoarchitectural pattern from the rest of the AI. Specifically, the ratio of SMI-32-positive pyramidal neurons to nonpyramidal neurons was larger in the dorsal high-frequency area than the rest of the AI. We named this new region the dorsomedial field (DM). Retrograde tracing showed that neurons projecting to the DM were localized in the rostral part of the ventral division of the medial geniculate body with a distinct frequency organization, where few neurons projected to the AI. Furthermore, the responses of the DM to ultrasonic courtship songs presented by males were significantly greater in females than in males; in contrast, there was no sex difference in response to artificial pure tones. Our findings offer a basic outline on the processing of ultrasonic vocal information on the basis of the precisely subdivided, multiple frequency-organized auditory cortex map in mice. American Physiological Society 2015-02-18 2015-04 /pmc/articles/PMC4416634/ /pubmed/25695649 http://dx.doi.org/10.1152/jn.00932.2014 Text en Copyright © 2015 the American Physiological Society Licensed under Creative Commons Attribution CC-BY 3.0 (http://creativecommons.org/licenses/by/3.0/deed.en_US) : © the American Physiological Society. |
spellingShingle | Sensory Processing Tsukano, Hiroaki Horie, Masao Bo, Takeshi Uchimura, Arikuni Hishida, Ryuichi Kudoh, Masaharu Takahashi, Kuniyuki Takebayashi, Hirohide Shibuki, Katsuei Delineation of a frequency-organized region isolated from the mouse primary auditory cortex |
title | Delineation of a frequency-organized region isolated from the mouse primary auditory cortex |
title_full | Delineation of a frequency-organized region isolated from the mouse primary auditory cortex |
title_fullStr | Delineation of a frequency-organized region isolated from the mouse primary auditory cortex |
title_full_unstemmed | Delineation of a frequency-organized region isolated from the mouse primary auditory cortex |
title_short | Delineation of a frequency-organized region isolated from the mouse primary auditory cortex |
title_sort | delineation of a frequency-organized region isolated from the mouse primary auditory cortex |
topic | Sensory Processing |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416634/ https://www.ncbi.nlm.nih.gov/pubmed/25695649 http://dx.doi.org/10.1152/jn.00932.2014 |
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