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AICAR-Induced Activation of AMPK Inhibits TSH/SREBP-2/HMGCR Pathway in Liver

Our previous study found that thyroid-stimulating hormone promoted sterol regulatory element-binding protein-2 (SREBP-2) expression and suppressed AMP-activated protein kinase (AMPK) activity in the liver, but it was unclear whether there was a direct link between TSH, AMPK and SREBP-2. Here, we dem...

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Detalles Bibliográficos
Autores principales: Liu, Shudong, Jing, Fei, Yu, Chunxiao, Gao, Ling, Qin, Yejun, Zhao, Jiajun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416759/
https://www.ncbi.nlm.nih.gov/pubmed/25933205
http://dx.doi.org/10.1371/journal.pone.0124951