Cargando…
AICAR-Induced Activation of AMPK Inhibits TSH/SREBP-2/HMGCR Pathway in Liver
Our previous study found that thyroid-stimulating hormone promoted sterol regulatory element-binding protein-2 (SREBP-2) expression and suppressed AMP-activated protein kinase (AMPK) activity in the liver, but it was unclear whether there was a direct link between TSH, AMPK and SREBP-2. Here, we dem...
Autores principales: | Liu, Shudong, Jing, Fei, Yu, Chunxiao, Gao, Ling, Qin, Yejun, Zhao, Jiajun |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416759/ https://www.ncbi.nlm.nih.gov/pubmed/25933205 http://dx.doi.org/10.1371/journal.pone.0124951 |
Ejemplares similares
-
Hypolipidemic properties of Chlorella pyrenoidosa organic acids via AMPK/HMGCR/SREBP‐1c pathway in vivo
por: Chen, Jie, et al.
Publicado: (2020) -
TSH promotes adiposity by inhibiting the browning of white fat
por: Zhang, Jianmei, et al.
Publicado: (2020) -
Therapeutic targets of hypercholesterolemia: HMGCR and LDLR
por: Ma, Shizhan, et al.
Publicado: (2019) -
AMPK-independent inhibition of human macrophage ER stress response by AICAR
por: Boß, Marcel, et al.
Publicado: (2016) -
AMPK agonist AICAR ameliorates portal hypertension and liver cirrhosis via NO pathway in the BDL rat model
por: Hu, Liangshuo, et al.
Publicado: (2019)