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Associated Factors for Tuberculosis Recurrence in Taiwan: A Nationwide Nested Case-Control Study from 1998 to 2010
BACKGROUND: The contribution of human immunodeficiency virus (HIV) co-infection to tuberculosis (TB) recurrence is well established worldwide. We conducted this study to investigate associated factors for recurrent TB in Taiwan, which has a relatively low prevalence of HIV. METHODS: A case-control s...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416773/ https://www.ncbi.nlm.nih.gov/pubmed/25932917 http://dx.doi.org/10.1371/journal.pone.0124822 |
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author | Hung, Chung-Lin Chien, Jung-Yien Ou, Chih-Ying |
author_facet | Hung, Chung-Lin Chien, Jung-Yien Ou, Chih-Ying |
author_sort | Hung, Chung-Lin |
collection | PubMed |
description | BACKGROUND: The contribution of human immunodeficiency virus (HIV) co-infection to tuberculosis (TB) recurrence is well established worldwide. We conducted this study to investigate associated factors for recurrent TB in Taiwan, which has a relatively low prevalence of HIV. METHODS: A case-control study nested within a nationwide population-based cohort was performed using the Taiwan National Health Insurance (NHI) database from 1998 to 2010. Patients with notified TB were identified according to diagnosis codes and prescriptions of anti-TB drugs for more than 60 days. Recurrent TB was defined as cases being retreated for more than 60 days and 6 months after the end of previous TB episode. Four controls were randomly selected from cohort and matched to each case by observational period within a calendar year. Socio-demographic variables and comorbidities were evaluated as factors associated with TB recurrence. RESULTS: There were totally 760 patients being investigated (608 controls and 152 cases). During an average 5.12 years of follow-up, 3.76% of all developed recurrent TB and the incidence of TB recurrence was 734 per 100,000 person-years. About half of recurrence (55%) was notified within three years of follow-up, and most (86%) recurrences were intrapulmonary. Independent associated factors for TB recurrence included: male (odds ratio, OR: 2.23, 95% confidence interval, CI: 1.40–3.53), diabetes mellitus (DM) (OR: 1.51, 95% CI: 1.02–2.13), chronic obstructive pulmonary disease (COPD) (OR: 1.59, 95% CI: 1.08–2.36) and lower socio-economic status (p=0.001 between groups). CONCLUSIONS: Despite low prevalence of HIV in the Taiwanese population, the incidence of recurrent TB among Taiwanese was not less than that of other countries. Identification of subgroups such as male gender, low economic status, DM and COPD should be a high priority in TB control programs. |
format | Online Article Text |
id | pubmed-4416773 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-44167732015-05-07 Associated Factors for Tuberculosis Recurrence in Taiwan: A Nationwide Nested Case-Control Study from 1998 to 2010 Hung, Chung-Lin Chien, Jung-Yien Ou, Chih-Ying PLoS One Research Article BACKGROUND: The contribution of human immunodeficiency virus (HIV) co-infection to tuberculosis (TB) recurrence is well established worldwide. We conducted this study to investigate associated factors for recurrent TB in Taiwan, which has a relatively low prevalence of HIV. METHODS: A case-control study nested within a nationwide population-based cohort was performed using the Taiwan National Health Insurance (NHI) database from 1998 to 2010. Patients with notified TB were identified according to diagnosis codes and prescriptions of anti-TB drugs for more than 60 days. Recurrent TB was defined as cases being retreated for more than 60 days and 6 months after the end of previous TB episode. Four controls were randomly selected from cohort and matched to each case by observational period within a calendar year. Socio-demographic variables and comorbidities were evaluated as factors associated with TB recurrence. RESULTS: There were totally 760 patients being investigated (608 controls and 152 cases). During an average 5.12 years of follow-up, 3.76% of all developed recurrent TB and the incidence of TB recurrence was 734 per 100,000 person-years. About half of recurrence (55%) was notified within three years of follow-up, and most (86%) recurrences were intrapulmonary. Independent associated factors for TB recurrence included: male (odds ratio, OR: 2.23, 95% confidence interval, CI: 1.40–3.53), diabetes mellitus (DM) (OR: 1.51, 95% CI: 1.02–2.13), chronic obstructive pulmonary disease (COPD) (OR: 1.59, 95% CI: 1.08–2.36) and lower socio-economic status (p=0.001 between groups). CONCLUSIONS: Despite low prevalence of HIV in the Taiwanese population, the incidence of recurrent TB among Taiwanese was not less than that of other countries. Identification of subgroups such as male gender, low economic status, DM and COPD should be a high priority in TB control programs. Public Library of Science 2015-05-01 /pmc/articles/PMC4416773/ /pubmed/25932917 http://dx.doi.org/10.1371/journal.pone.0124822 Text en © 2015 Hung et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Hung, Chung-Lin Chien, Jung-Yien Ou, Chih-Ying Associated Factors for Tuberculosis Recurrence in Taiwan: A Nationwide Nested Case-Control Study from 1998 to 2010 |
title | Associated Factors for Tuberculosis Recurrence in Taiwan: A Nationwide Nested Case-Control Study from 1998 to 2010 |
title_full | Associated Factors for Tuberculosis Recurrence in Taiwan: A Nationwide Nested Case-Control Study from 1998 to 2010 |
title_fullStr | Associated Factors for Tuberculosis Recurrence in Taiwan: A Nationwide Nested Case-Control Study from 1998 to 2010 |
title_full_unstemmed | Associated Factors for Tuberculosis Recurrence in Taiwan: A Nationwide Nested Case-Control Study from 1998 to 2010 |
title_short | Associated Factors for Tuberculosis Recurrence in Taiwan: A Nationwide Nested Case-Control Study from 1998 to 2010 |
title_sort | associated factors for tuberculosis recurrence in taiwan: a nationwide nested case-control study from 1998 to 2010 |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416773/ https://www.ncbi.nlm.nih.gov/pubmed/25932917 http://dx.doi.org/10.1371/journal.pone.0124822 |
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