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Understanding the Impact of Hazardous and Harmful Use of Alcohol and/or Other Drugs on ARV Adherence and Disease Progression

The objective of this study was to understand the impact of hazardous and harmful use of alcohol and/or other drugs on ARV adherence and disease progression among HIV patients. A cross-sectional study design was used. A total of 1503 patients attending HIV clinics in Cape Town, South Africa were scr...

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Detalles Bibliográficos
Autores principales: Kader, Rehana, Govender, Rajen, Seedat, Soraya, Koch, John Randy, Parry, Charles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416796/
https://www.ncbi.nlm.nih.gov/pubmed/25933422
http://dx.doi.org/10.1371/journal.pone.0125088
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author Kader, Rehana
Govender, Rajen
Seedat, Soraya
Koch, John Randy
Parry, Charles
author_facet Kader, Rehana
Govender, Rajen
Seedat, Soraya
Koch, John Randy
Parry, Charles
author_sort Kader, Rehana
collection PubMed
description The objective of this study was to understand the impact of hazardous and harmful use of alcohol and/or other drugs on ARV adherence and disease progression among HIV patients. A cross-sectional study design was used. A total of 1503 patients attending HIV clinics in Cape Town, South Africa were screened for problematic substance use. A sub-sample of 607 patients (303 patients who screened positive for problematic substance use and 304 who did not) participated in this study. Hazardous or harmful alcohol use and problematic drug use predicted missing and stopping ARVs which, in turn, was associated with a decrease in CD4 counts and more rapid HIV-disease progression and poorer health outcomes in people living with HIV/AIDS (PLWHA). The findings of this study underscore the need for an integrated approach to managing substance-use disorders in PLWHA.
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spelling pubmed-44167962015-05-07 Understanding the Impact of Hazardous and Harmful Use of Alcohol and/or Other Drugs on ARV Adherence and Disease Progression Kader, Rehana Govender, Rajen Seedat, Soraya Koch, John Randy Parry, Charles PLoS One Research Article The objective of this study was to understand the impact of hazardous and harmful use of alcohol and/or other drugs on ARV adherence and disease progression among HIV patients. A cross-sectional study design was used. A total of 1503 patients attending HIV clinics in Cape Town, South Africa were screened for problematic substance use. A sub-sample of 607 patients (303 patients who screened positive for problematic substance use and 304 who did not) participated in this study. Hazardous or harmful alcohol use and problematic drug use predicted missing and stopping ARVs which, in turn, was associated with a decrease in CD4 counts and more rapid HIV-disease progression and poorer health outcomes in people living with HIV/AIDS (PLWHA). The findings of this study underscore the need for an integrated approach to managing substance-use disorders in PLWHA. Public Library of Science 2015-05-01 /pmc/articles/PMC4416796/ /pubmed/25933422 http://dx.doi.org/10.1371/journal.pone.0125088 Text en © 2015 Kader et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Kader, Rehana
Govender, Rajen
Seedat, Soraya
Koch, John Randy
Parry, Charles
Understanding the Impact of Hazardous and Harmful Use of Alcohol and/or Other Drugs on ARV Adherence and Disease Progression
title Understanding the Impact of Hazardous and Harmful Use of Alcohol and/or Other Drugs on ARV Adherence and Disease Progression
title_full Understanding the Impact of Hazardous and Harmful Use of Alcohol and/or Other Drugs on ARV Adherence and Disease Progression
title_fullStr Understanding the Impact of Hazardous and Harmful Use of Alcohol and/or Other Drugs on ARV Adherence and Disease Progression
title_full_unstemmed Understanding the Impact of Hazardous and Harmful Use of Alcohol and/or Other Drugs on ARV Adherence and Disease Progression
title_short Understanding the Impact of Hazardous and Harmful Use of Alcohol and/or Other Drugs on ARV Adherence and Disease Progression
title_sort understanding the impact of hazardous and harmful use of alcohol and/or other drugs on arv adherence and disease progression
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416796/
https://www.ncbi.nlm.nih.gov/pubmed/25933422
http://dx.doi.org/10.1371/journal.pone.0125088
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