Pharmacological Inhibition of ULK1 Kinase Blocks Mammalian Target of Rapamycin (mTOR)-dependent Autophagy

Autophagy is a cell-protective and degradative process that recycles damaged and long-lived cellular components. Cancer cells are thought to take advantage of autophagy to help them to cope with the stress of tumorigenesis; thus targeting autophagy is an attractive therapeutic approach. However, the...

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Detalles Bibliográficos
Autores principales: Petherick, Katy J., Conway, Owen J. L., Mpamhanga, Chido, Osborne, Simon A., Kamal, Ahmad, Saxty, Barbara, Ganley, Ian G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2015
Materias:
Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416842/
https://www.ncbi.nlm.nih.gov/pubmed/25833948
http://dx.doi.org/10.1074/jbc.C114.627778

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416842/
https://www.ncbi.nlm.nih.gov/pubmed/25833948
http://dx.doi.org/10.1074/jbc.C114.627778

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