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Extra-Nuclear Signaling Pathway Involved in Progesterone-Induced Up-Regulations of p21(cip1) and p27(kip1) in Male Rat Aortic Smooth Muscle Cells
Previously, we demonstrated that progesterone (P4) at physiologic levels (5-500 nM) inhibited proliferation in cultured rat aortic smooth muscle cells (RASMCs) through a P4 receptor (PR)-dependent pathway. We also showed that P4-induced cell cycle arrest in RASMCs occurs when the cyclin-CDK2 system...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416894/ https://www.ncbi.nlm.nih.gov/pubmed/25932965 http://dx.doi.org/10.1371/journal.pone.0125903 |