Heme activation by DNA: isoguanine pentaplexes, but not quadruplexes, bind heme and enhance its oxidative activity

Guanine-rich, single-stranded, DNAs and RNAs are able to fold to form G-quadruplexes that are held together by guanine base quartets. G-quadruplexes are known to bind ferric heme [Fe(III)-protoporphyrin IX] and to strongly activate such bound hemes toward peroxidase (1-electron oxidation) as well as...

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Detalles Bibliográficos
Autores principales: Shumayrikh, Nisreen, Huang, Yu Chuan, Sen, Dipankar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417173/
https://www.ncbi.nlm.nih.gov/pubmed/25824944
http://dx.doi.org/10.1093/nar/gkv266

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417173/
https://www.ncbi.nlm.nih.gov/pubmed/25824944
http://dx.doi.org/10.1093/nar/gkv266

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