Activated microglia/macrophage whey acidic protein (AMWAP) inhibits NFκB signaling and induces a neuroprotective phenotype in microglia

BACKGROUND: Microglia reactivity is a hallmark of neurodegenerative diseases. We have previously identified activated microglia/macrophage whey acidic protein (AMWAP) as a counter-regulator of pro-inflammatory response. Here, we studied its mechanisms of action with a focus on toll-like receptor (TL...

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Detalles Bibliográficos
Autores principales: Aslanidis, Alexander, Karlstetter, Marcus, Scholz, Rebecca, Fauser, Sascha, Neumann, Harald, Fried, Cora, Pietsch, Markus, Langmann, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417279/
https://www.ncbi.nlm.nih.gov/pubmed/25928566
http://dx.doi.org/10.1186/s12974-015-0296-6

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