Cargando…

Copy-neutral loss of heterozygosity and chromosome gains and losses are frequent in gastrointestinal stromal tumors

BACKGROUND: A KIT gain of function mutation is present in 70% of gastrointestinal stromal tumors (GISTs) and the wild-type (WT) allele is deleted in 5 to 15% of these cases. The WT KIT is probably deleted during GIST progression. We aimed to identify the mechanism of WT KIT loss and to determine whe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lourenço, Nelson, Hélias-Rodzewicz, Zofia, Bachet, Jean-Baptiste, Brahimi-Adouane, Sabrina, Jardin, Fabrice, Tran van Nhieu, Jeanne, Peschaud, Frédérique, Martin, Emmanuel, Beauchet, Alain, Chibon, Frédéric, Emile, Jean-François
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417285/ https://www.ncbi.nlm.nih.gov/pubmed/25373456 http://dx.doi.org/10.1186/1476-4598-13-246

Ejemplares similares

Variation of mutant allele frequency in NRAS Q61 mutated melanomas
por: Hélias-Rodzewicz, Zofia, et al.
Publicado: (2017)

Gene Expression Patterns of Hemizygous and Heterozygous KIT Mutations Suggest Distinct Oncogenic Pathways: A Study in NIH3T3 Cell Lines and GIST Samples
por: Bachet, Jean-Baptiste, et al.
Publicado: (2013)

Variations of BRAF mutant allele percentage in melanomas
por: Hélias-Rodzewicz, Zofia, et al.
Publicado: (2015)

Frequent loss of heterozygosity on chromosome 6 in human ovarian carcinoma.
por: Foulkes, W. D., et al.
Publicado: (1993)

Frequent Loss of Heterozygosity on Chromosomes 16 and 4 in Human Hepatocellular Carcinoma
por: Zhang, Wandong, et al.
Publicado: (1990)

Somatic mosaicism for copy-neutral loss of heterozygosity and DNA copy number variations in the human genome
por: Žilina, Olga, et al.
Publicado: (2015)

Loss of Heterozygosity and Copy Number Alterations in Flow-Sorted Bulky Cervical Cancer
por: van den Tillaart, Sabrina A. H. M., et al.
Publicado: (2013)

Functional Polymorphism of the Thymidylate Synthase Gene in Colorectal Cancer Accompanied by Frequent Loss of Heterozygosity
por: Kawakami, Kazuyuki, et al.
Publicado: (2002)

Frequent somatic gene conversion as a mechanism for loss of heterozygosity in tumor suppressor genes
por: Takahashi, Kazuki K., et al.
Publicado: (2022)

Loss of heterozygosity of TRIM3 in malignant gliomas
por: Boulay, Jean-Louis, et al.
Publicado: (2009)

Neuroendocrine Carcinoma of the Kidney and Bladder with Loss of Heterozygosity and Changes in Chromosome 3 Copy Number
por: Okada, Atsushi, et al.
Publicado: (2015)

Impact of Copy Neutral Loss of Heterozygosity and Total Genome Aberrations on Survival in Myelodysplastic Syndrome
por: Yeung, Cecilia, et al.
Publicado: (2017)

Comprehensive SNP array study of frequently used neuroblastoma cell lines; copy neutral loss of heterozygosity is common in the cell lines but uncommon in primary tumors
por: Kryh, Hanna, et al.
Publicado: (2011)

Loss of heterozygosity: what is it good for?
por: Ryland, Georgina L., et al.
Publicado: (2015)

Y(MAP): a pipeline for visualization of copy number variation and loss of heterozygosity in eukaryotic pathogens
por: Abbey, Darren A, et al.
Publicado: (2014)

Frequent loss of heterozygosity on chromosome 17 at 17q11.2-q12 in Barrett's adenocarcinoma.
por: Swift, A., et al.
Publicado: (1995)

Frequent loss of heterozygosity and altered expression of the candidate tumor suppressor gene 'FAT' in human astrocytic tumors
por: Chosdol, Kunzang, et al.
Publicado: (2009)

Frequent Loss of Heterozygosity at the MCC Locus on Chromosome 5q21‐22 in Sporadic Colorectal Carcinomas
por: Miki, Yoshio, et al.
Publicado: (1991)

Loss of Heterozygosity and Its Importance in Evolution
por: Smukowski Heil, Caiti
Publicado: (2023)

SNP Array Analysis Reveals Novel Genomic Abnormalities Including Copy Neutral Loss of Heterozygosity in Anaplastic Oligodendrogliomas
por: Idbaih, Ahmed, et al.
Publicado: (2012)

Dissecting Loss of Heterozygosity (LOH) in Neurofibromatosis Type 1-Associated Neurofibromas: Importance of Copy Neutral LOH
por: Garcia-Linares, Carles, et al.
Publicado: (2011)

Copy-neutral loss of heterozygosity is prevalent and a late event in the pathogenesis of FLT3/ITD AML
por: Stirewalt, D L, et al.
Publicado: (2014)

Clonal evidence for the development of neuroblastoma with extensive copy‐neutral loss of heterozygosity arising in a mature teratoma
por: Ono, Rintaro, et al.
Publicado: (2021)

Improvement of the quality of BRAF testing in melanomas with nationwide external quality assessment, for the BRAF EQA group
por: Emile, Jean-François, et al.
Publicado: (2013)

A new method to detect loss of heterozygosity using cohort heterozygosity comparisons
por: Green, Michael R, et al.
Publicado: (2010)

Correction: SNP Array Analysis Reveals Novel Genomic Abnormalities Including Copy Neutral Loss of Heterozygosity in Anaplastic Oligodendrogliomas
por: Idbaih, Ahmed, et al.
Publicado: (2013)

Copy Number and Loss of Heterozygosity Detected by SNP Array of Formalin-Fixed Tissues Using Whole-Genome Amplification
por: Stokes, Angela, et al.
Publicado: (2011)

Copy number of the Adenomatous Polyposis Coli gene is not always neutral in sporadic colorectal cancers with loss of heterozygosity for the gene
por: Zauber, Peter, et al.
Publicado: (2016)

Massive interstitial copy-neutral loss-of-heterozygosity as evidence for cancer being a disease of the DNA-damage response
por: Kumar, Yogesh, et al.
Publicado: (2015)

Allele-specific genomic data elucidate the role of somatic gain and copy-number neutral loss of heterozygosity in cancer
por: Ciani, Yari, et al.
Publicado: (2022)

Genome-wide identification of copy neutral loss of heterozygosity reveals its possible association with spatial positioning of chromosomes
por: Kim, Hyeonjeong, et al.
Publicado: (2022)

Analysis of Loss of Heterozygosity in Korean Patients with Keratoacanthoma
por: Ha, Tae-Won, et al.
Publicado: (2005)

Loss of Heterozygosity Drives Adaptation in Hybrid Yeast
por: Smukowski Heil, Caiti S., et al.
Publicado: (2017)

Targeting tumor vulnerabilities associated with loss of heterozygosity
por: Rendo, Veronica, et al.
Publicado: (2020)

Fitness benefits of loss of heterozygosity in Saccharomyces hybrids
por: Lancaster, Samuel M., et al.
Publicado: (2019)

Targeting loss of heterozygosity for cancer-specific immunotherapy
por: Hwang, Michael S., et al.
Publicado: (2021)

Polyploidy as an Adaptation against Loss of Heterozygosity in Cancer
por: Archetti, Marco
Publicado: (2022)

Ataxia-Telangiectasia Mutated Loss of Heterozygosity in Melanoma
por: Pastorino, Lorenza, et al.
Publicado: (2022)

PTEN/MMAC1 Mutation and Frequent Loss of Heterozygosity Identified in Chromosome 10q in a Subset of Hepatocellular Carcinomas
por: Fujiwara, Yoshiyuki, et al.
Publicado: (2000)

Diagnostic criteria, specific mutations, and genetic predisposition in gastrointestinal stromal tumors
por: Bachet, Jean-Baptiste, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_6ngi2hbv88n9fnaukp6br7je9n