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KLF5 inhibits angiogenesis in PTEN-deficient prostate cancer by attenuating AKT activation and subsequent HIF1α accumulation

BACKGROUND: KLF5 is a basic transcriptional factor that regulates multiple physiopathological processes. Our recent study showed that deletion of Klf5 in mouse prostate promotes tumorigenesis initiated by the deletion of Pten. While molecular characterization of Klf5-null tumors suggested that angio...

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Detalles Bibliográficos
Autores principales:	Ci, Xinpei, Xing, Changsheng, Zhang, Baotong, Zhang, Zhiqian, Ni, Jenny Jianping, Zhou, Wei, Dong, Jin-Tang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417294/ https://www.ncbi.nlm.nih.gov/pubmed/25896712 http://dx.doi.org/10.1186/s12943-015-0365-6

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