Association of MRS-Based Vertebral Bone Marrow Fat Fraction with Bone Strength in a Human In Vitro Model

Bone marrow adiposity has recently gained attention due to its association with bone loss pathophysiology. In this study, ten vertebrae were harvested from fresh human cadavers. Trabecular BMD and microstructure parameters were extracted from MDCT. Bone marrow fat fractions were determined using sin...

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Autores principales: Karampinos, Dimitrios C., Ruschke, Stefan, Gordijenko, Olga, Grande Garcia, Eduardo, Kooijman, Hendrik, Burgkart, Rainer, Rummeny, Ernst J., Bauer, Jan S., Baum, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417596/
https://www.ncbi.nlm.nih.gov/pubmed/25969766
http://dx.doi.org/10.1155/2015/152349
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author Karampinos, Dimitrios C.
Ruschke, Stefan
Gordijenko, Olga
Grande Garcia, Eduardo
Kooijman, Hendrik
Burgkart, Rainer
Rummeny, Ernst J.
Bauer, Jan S.
Baum, Thomas
author_facet Karampinos, Dimitrios C.
Ruschke, Stefan
Gordijenko, Olga
Grande Garcia, Eduardo
Kooijman, Hendrik
Burgkart, Rainer
Rummeny, Ernst J.
Bauer, Jan S.
Baum, Thomas
author_sort Karampinos, Dimitrios C.
collection PubMed
description Bone marrow adiposity has recently gained attention due to its association with bone loss pathophysiology. In this study, ten vertebrae were harvested from fresh human cadavers. Trabecular BMD and microstructure parameters were extracted from MDCT. Bone marrow fat fractions were determined using single-voxel MRS. Failure load (FL) values were assessed by destructive biomechanical testing. Significant correlations (P < 0.05) were observed between MRS-based fat fraction and MDCT-based parameters (up to r = −0.72) and MRS-based fat fraction and FL (r = −0.77). These findings underline the importance of the bone marrow in the pathophysiology and imaging diagnostics of osteoporosis.
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spelling pubmed-44175962015-05-12 Association of MRS-Based Vertebral Bone Marrow Fat Fraction with Bone Strength in a Human In Vitro Model Karampinos, Dimitrios C. Ruschke, Stefan Gordijenko, Olga Grande Garcia, Eduardo Kooijman, Hendrik Burgkart, Rainer Rummeny, Ernst J. Bauer, Jan S. Baum, Thomas J Osteoporos Research Article Bone marrow adiposity has recently gained attention due to its association with bone loss pathophysiology. In this study, ten vertebrae were harvested from fresh human cadavers. Trabecular BMD and microstructure parameters were extracted from MDCT. Bone marrow fat fractions were determined using single-voxel MRS. Failure load (FL) values were assessed by destructive biomechanical testing. Significant correlations (P < 0.05) were observed between MRS-based fat fraction and MDCT-based parameters (up to r = −0.72) and MRS-based fat fraction and FL (r = −0.77). These findings underline the importance of the bone marrow in the pathophysiology and imaging diagnostics of osteoporosis. Hindawi Publishing Corporation 2015 2015-04-19 /pmc/articles/PMC4417596/ /pubmed/25969766 http://dx.doi.org/10.1155/2015/152349 Text en Copyright © 2015 Dimitrios C. Karampinos et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Karampinos, Dimitrios C.
Ruschke, Stefan
Gordijenko, Olga
Grande Garcia, Eduardo
Kooijman, Hendrik
Burgkart, Rainer
Rummeny, Ernst J.
Bauer, Jan S.
Baum, Thomas
Association of MRS-Based Vertebral Bone Marrow Fat Fraction with Bone Strength in a Human In Vitro Model
title Association of MRS-Based Vertebral Bone Marrow Fat Fraction with Bone Strength in a Human In Vitro Model
title_full Association of MRS-Based Vertebral Bone Marrow Fat Fraction with Bone Strength in a Human In Vitro Model
title_fullStr Association of MRS-Based Vertebral Bone Marrow Fat Fraction with Bone Strength in a Human In Vitro Model
title_full_unstemmed Association of MRS-Based Vertebral Bone Marrow Fat Fraction with Bone Strength in a Human In Vitro Model
title_short Association of MRS-Based Vertebral Bone Marrow Fat Fraction with Bone Strength in a Human In Vitro Model
title_sort association of mrs-based vertebral bone marrow fat fraction with bone strength in a human in vitro model
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417596/
https://www.ncbi.nlm.nih.gov/pubmed/25969766
http://dx.doi.org/10.1155/2015/152349
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