Cargando…
TP53 loss creates therapeutic vulnerability in colorectal cancer
TP53 , a well-known tumour suppressor gene, is frequently inactivated by mutation or deletion in a majority of human tumours(1,2). A tremendous effort has been made to restore p53 activity in cancer therapies(3–7). However, no effective p53-based therapy has been successfully translated into clinica...
Autores principales: | Liu, Yunhua, Zhang, Xinna, Han, Cecil, Wan, Guohui, Huang, Xingxu, Ivan, Cristina, Jiang, Dahai, Rodriguez-Aguayo, Cristian, Lopez-Berestein, Gabriel, Rao, Pulivarthi H., Maru, Dipen M., Pahl, Andreas, He, Xiaoming, Sood, Anil K., Ellis, Lee M., Anderl, Jan, Lu, Xiongbin |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417759/ https://www.ncbi.nlm.nih.gov/pubmed/25901683 http://dx.doi.org/10.1038/nature14418 |
Ejemplares similares
-
Amplification of USP13 drives ovarian cancer metabolism
por: Han, Cecil, et al.
Publicado: (2016) -
PRKAR1B-AS2 Long Noncoding RNA Promotes Tumorigenesis, Survival, and Chemoresistance via the PI3K/AKT/mTOR Pathway
por: Elsayed, Abdelrahman M., et al.
Publicado: (2021) -
Heterozygous deletion of chromosome 17p renders prostate cancer vulnerable to inhibition of RNA polymerase II
por: Li, Yujing, et al.
Publicado: (2018) -
Therapeutic evaluation of microRNA-15a and microRNA-16 in ovarian cancer
por: Dhar Dwivedi, Shailendra Kumar, et al.
Publicado: (2016) -
Enhancing Chemotherapy Response with Bmi-1 Silencing in Ovarian
Cancer
por: Wang, Enfeng, et al.
Publicado: (2011)