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Constraint and divergence of global gene expression in the mammalian embryo

The effects of genetic variation on gene regulation in the developing mammalian embryo remain largely unexplored. To globally quantify these effects, we crossed two divergent mouse strains and asked how genotype of the mother or of the embryo drives gene expression phenotype genomewide. Embryonic ex...

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Detalles Bibliográficos
Autores principales: Spies, Noah, Smith, Cheryl L, Rodriguez, Jesse M, Baker, Julie C, Batzoglou, Serafim, Sidow, Arend
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417935/
https://www.ncbi.nlm.nih.gov/pubmed/25871848
http://dx.doi.org/10.7554/eLife.05538