Clostridium Perfringens Enterotoxin (CPE) and CPE-Binding Domain (c-CPE) for the Detection and Treatment of Gynecologic Cancers

Clostridium perfringens enterotoxin (CPE) is a three-domain polypeptide, which binds to Claudin-3 and Claudin-4 with high affinity. Because these receptors are highly differentially expressed in many human tumors, claudin-3 and claudin-4 may provide an efficient molecular tool to specifically identi...

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Autores principales: Black, Jonathan D., Lopez, Salvatore, Cocco, Emiliano, Schwab, Carlton L., English, Diana P., Santin, Alessandro D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417958/
https://www.ncbi.nlm.nih.gov/pubmed/25835384
http://dx.doi.org/10.3390/toxins7041116
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author Black, Jonathan D.
Lopez, Salvatore
Cocco, Emiliano
Schwab, Carlton L.
English, Diana P.
Santin, Alessandro D.
author_facet Black, Jonathan D.
Lopez, Salvatore
Cocco, Emiliano
Schwab, Carlton L.
English, Diana P.
Santin, Alessandro D.
author_sort Black, Jonathan D.
collection PubMed
description Clostridium perfringens enterotoxin (CPE) is a three-domain polypeptide, which binds to Claudin-3 and Claudin-4 with high affinity. Because these receptors are highly differentially expressed in many human tumors, claudin-3 and claudin-4 may provide an efficient molecular tool to specifically identify and target biologically aggressive human cancer cells for CPE-specific binding and cytolysis. In this review we will discuss these surface proteins as targets for the detection and treatment of chemotherapy-resistant gynecologic malignancies overexpressing claudin-3 and -4 using CPE-based theranostic agents. We will also discuss the use of fluorescent c-CPE peptide in the operative setting for real time detection of micro-metastatic tumors during surgery and review the potential role of CPE in other medical applications.
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spelling pubmed-44179582015-05-18 Clostridium Perfringens Enterotoxin (CPE) and CPE-Binding Domain (c-CPE) for the Detection and Treatment of Gynecologic Cancers Black, Jonathan D. Lopez, Salvatore Cocco, Emiliano Schwab, Carlton L. English, Diana P. Santin, Alessandro D. Toxins (Basel) Review Clostridium perfringens enterotoxin (CPE) is a three-domain polypeptide, which binds to Claudin-3 and Claudin-4 with high affinity. Because these receptors are highly differentially expressed in many human tumors, claudin-3 and claudin-4 may provide an efficient molecular tool to specifically identify and target biologically aggressive human cancer cells for CPE-specific binding and cytolysis. In this review we will discuss these surface proteins as targets for the detection and treatment of chemotherapy-resistant gynecologic malignancies overexpressing claudin-3 and -4 using CPE-based theranostic agents. We will also discuss the use of fluorescent c-CPE peptide in the operative setting for real time detection of micro-metastatic tumors during surgery and review the potential role of CPE in other medical applications. MDPI 2015-04-01 /pmc/articles/PMC4417958/ /pubmed/25835384 http://dx.doi.org/10.3390/toxins7041116 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Black, Jonathan D.
Lopez, Salvatore
Cocco, Emiliano
Schwab, Carlton L.
English, Diana P.
Santin, Alessandro D.
Clostridium Perfringens Enterotoxin (CPE) and CPE-Binding Domain (c-CPE) for the Detection and Treatment of Gynecologic Cancers
title Clostridium Perfringens Enterotoxin (CPE) and CPE-Binding Domain (c-CPE) for the Detection and Treatment of Gynecologic Cancers
title_full Clostridium Perfringens Enterotoxin (CPE) and CPE-Binding Domain (c-CPE) for the Detection and Treatment of Gynecologic Cancers
title_fullStr Clostridium Perfringens Enterotoxin (CPE) and CPE-Binding Domain (c-CPE) for the Detection and Treatment of Gynecologic Cancers
title_full_unstemmed Clostridium Perfringens Enterotoxin (CPE) and CPE-Binding Domain (c-CPE) for the Detection and Treatment of Gynecologic Cancers
title_short Clostridium Perfringens Enterotoxin (CPE) and CPE-Binding Domain (c-CPE) for the Detection and Treatment of Gynecologic Cancers
title_sort clostridium perfringens enterotoxin (cpe) and cpe-binding domain (c-cpe) for the detection and treatment of gynecologic cancers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417958/
https://www.ncbi.nlm.nih.gov/pubmed/25835384
http://dx.doi.org/10.3390/toxins7041116
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