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Application of Metabolomics in Thyroid Cancer Research

Thyroid cancer is the most common endocrine malignancy with four major types distinguished on the basis of histopathological features: papillary, follicular, medullary, and anaplastic. Classification of thyroid cancer is the primary step in the assessment of prognosis and selection of the treatment....

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Autores principales: Wojakowska, Anna, Chekan, Mykola, Widlak, Piotr, Pietrowska, Monika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417976/
https://www.ncbi.nlm.nih.gov/pubmed/25972898
http://dx.doi.org/10.1155/2015/258763
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author Wojakowska, Anna
Chekan, Mykola
Widlak, Piotr
Pietrowska, Monika
author_facet Wojakowska, Anna
Chekan, Mykola
Widlak, Piotr
Pietrowska, Monika
author_sort Wojakowska, Anna
collection PubMed
description Thyroid cancer is the most common endocrine malignancy with four major types distinguished on the basis of histopathological features: papillary, follicular, medullary, and anaplastic. Classification of thyroid cancer is the primary step in the assessment of prognosis and selection of the treatment. However, in some cases, cytological and histological patterns are inconclusive; hence, classification based on histopathology could be supported by molecular biomarkers, including markers identified with the use of high-throughput “omics” techniques. Beside genomics, transcriptomics, and proteomics, metabolomic approach emerges as the most downstream attitude reflecting phenotypic changes and alterations in pathophysiological states of biological systems. Metabolomics using mass spectrometry and magnetic resonance spectroscopy techniques allows qualitative and quantitative profiling of small molecules present in biological systems. This approach can be applied to reveal metabolic differences between different types of thyroid cancer and to identify new potential candidates for molecular biomarkers. In this review, we consider current results concerning application of metabolomics in the field of thyroid cancer research. Recent studies show that metabolomics can provide significant information about the discrimination between different types of thyroid lesions. In the near future, one could expect a further progress in thyroid cancer metabolomics leading to development of molecular markers and improvement of the tumor types classification and diagnosis.
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spelling pubmed-44179762015-05-13 Application of Metabolomics in Thyroid Cancer Research Wojakowska, Anna Chekan, Mykola Widlak, Piotr Pietrowska, Monika Int J Endocrinol Review Article Thyroid cancer is the most common endocrine malignancy with four major types distinguished on the basis of histopathological features: papillary, follicular, medullary, and anaplastic. Classification of thyroid cancer is the primary step in the assessment of prognosis and selection of the treatment. However, in some cases, cytological and histological patterns are inconclusive; hence, classification based on histopathology could be supported by molecular biomarkers, including markers identified with the use of high-throughput “omics” techniques. Beside genomics, transcriptomics, and proteomics, metabolomic approach emerges as the most downstream attitude reflecting phenotypic changes and alterations in pathophysiological states of biological systems. Metabolomics using mass spectrometry and magnetic resonance spectroscopy techniques allows qualitative and quantitative profiling of small molecules present in biological systems. This approach can be applied to reveal metabolic differences between different types of thyroid cancer and to identify new potential candidates for molecular biomarkers. In this review, we consider current results concerning application of metabolomics in the field of thyroid cancer research. Recent studies show that metabolomics can provide significant information about the discrimination between different types of thyroid lesions. In the near future, one could expect a further progress in thyroid cancer metabolomics leading to development of molecular markers and improvement of the tumor types classification and diagnosis. Hindawi Publishing Corporation 2015 2015-04-20 /pmc/articles/PMC4417976/ /pubmed/25972898 http://dx.doi.org/10.1155/2015/258763 Text en Copyright © 2015 Anna Wojakowska et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Wojakowska, Anna
Chekan, Mykola
Widlak, Piotr
Pietrowska, Monika
Application of Metabolomics in Thyroid Cancer Research
title Application of Metabolomics in Thyroid Cancer Research
title_full Application of Metabolomics in Thyroid Cancer Research
title_fullStr Application of Metabolomics in Thyroid Cancer Research
title_full_unstemmed Application of Metabolomics in Thyroid Cancer Research
title_short Application of Metabolomics in Thyroid Cancer Research
title_sort application of metabolomics in thyroid cancer research
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417976/
https://www.ncbi.nlm.nih.gov/pubmed/25972898
http://dx.doi.org/10.1155/2015/258763
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