Alzheimer's Pathogenesis and Its Link to the Mitochondrion

Alzheimer's disease (AD) is the most common form of dementia in the elderly. This neurodegenerative disorder is clinically characterized by impairment of cognitive functions and changes in behaviour and personality. The pathogenesis of AD is still unclear. Recent evidence supports some role of...

Descripción completa

Detalles Bibliográficos
Autores principales: Simoncini, C., Orsucci, D., Caldarazzo Ienco, E., Siciliano, G., Bonuccelli, U., Mancuso, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417983/
https://www.ncbi.nlm.nih.gov/pubmed/25973139
http://dx.doi.org/10.1155/2015/803942
_version_ 1782369417108127744
author Simoncini, C.
Orsucci, D.
Caldarazzo Ienco, E.
Siciliano, G.
Bonuccelli, U.
Mancuso, M.
author_facet Simoncini, C.
Orsucci, D.
Caldarazzo Ienco, E.
Siciliano, G.
Bonuccelli, U.
Mancuso, M.
author_sort Simoncini, C.
collection PubMed
description Alzheimer's disease (AD) is the most common form of dementia in the elderly. This neurodegenerative disorder is clinically characterized by impairment of cognitive functions and changes in behaviour and personality. The pathogenesis of AD is still unclear. Recent evidence supports some role of mitochondria dysfunction and oxidative stress in the development of the neurodegenerative process. In this review, we discuss the role of mitochondrial dysfunction in AD, focusing on the mechanisms that lead to mitochondrial impairment, oxidative stress, and neurodegeneration, a “vicious circle” that ends in dementia.
format Online
Article
Text
id pubmed-4417983
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-44179832015-05-13 Alzheimer's Pathogenesis and Its Link to the Mitochondrion Simoncini, C. Orsucci, D. Caldarazzo Ienco, E. Siciliano, G. Bonuccelli, U. Mancuso, M. Oxid Med Cell Longev Review Article Alzheimer's disease (AD) is the most common form of dementia in the elderly. This neurodegenerative disorder is clinically characterized by impairment of cognitive functions and changes in behaviour and personality. The pathogenesis of AD is still unclear. Recent evidence supports some role of mitochondria dysfunction and oxidative stress in the development of the neurodegenerative process. In this review, we discuss the role of mitochondrial dysfunction in AD, focusing on the mechanisms that lead to mitochondrial impairment, oxidative stress, and neurodegeneration, a “vicious circle” that ends in dementia. Hindawi Publishing Corporation 2015 2015-04-20 /pmc/articles/PMC4417983/ /pubmed/25973139 http://dx.doi.org/10.1155/2015/803942 Text en Copyright © 2015 C. Simoncini et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Simoncini, C.
Orsucci, D.
Caldarazzo Ienco, E.
Siciliano, G.
Bonuccelli, U.
Mancuso, M.
Alzheimer's Pathogenesis and Its Link to the Mitochondrion
title Alzheimer's Pathogenesis and Its Link to the Mitochondrion
title_full Alzheimer's Pathogenesis and Its Link to the Mitochondrion
title_fullStr Alzheimer's Pathogenesis and Its Link to the Mitochondrion
title_full_unstemmed Alzheimer's Pathogenesis and Its Link to the Mitochondrion
title_short Alzheimer's Pathogenesis and Its Link to the Mitochondrion
title_sort alzheimer's pathogenesis and its link to the mitochondrion
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417983/
https://www.ncbi.nlm.nih.gov/pubmed/25973139
http://dx.doi.org/10.1155/2015/803942
work_keys_str_mv AT simoncinic alzheimerspathogenesisanditslinktothemitochondrion
AT orsuccid alzheimerspathogenesisanditslinktothemitochondrion
AT caldarazzoiencoe alzheimerspathogenesisanditslinktothemitochondrion
AT sicilianog alzheimerspathogenesisanditslinktothemitochondrion
AT bonuccelliu alzheimerspathogenesisanditslinktothemitochondrion
AT mancusom alzheimerspathogenesisanditslinktothemitochondrion

Ejemplares similares