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Epigenetic Control of Interferon-Gamma Expression in CD8 T Cells
Interferon- (IFN-) γ is an essential cytokine for immunity against intracellular pathogens and cancer. IFN-γ expression by CD4 T lymphocytes is observed only after T helper (Th) 1 differentiation and there are several studies about the molecular mechanisms that control Ifng expression in these cells...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418004/ https://www.ncbi.nlm.nih.gov/pubmed/25973438 http://dx.doi.org/10.1155/2015/849573 |
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author | de Araújo-Souza, Patrícia S. Hanschke, Steffi C. H. Viola, João P. B. |
author_facet | de Araújo-Souza, Patrícia S. Hanschke, Steffi C. H. Viola, João P. B. |
author_sort | de Araújo-Souza, Patrícia S. |
collection | PubMed |
description | Interferon- (IFN-) γ is an essential cytokine for immunity against intracellular pathogens and cancer. IFN-γ expression by CD4 T lymphocytes is observed only after T helper (Th) 1 differentiation and there are several studies about the molecular mechanisms that control Ifng expression in these cells. However, naïve CD8 T lymphocytes do not produce large amounts of IFN-γ, but after TCR stimulation there is a progressive acquisition of IFN-γ expression during differentiation into cytotoxic T lymphocytes (CTL) and memory cells, which are capable of producing high levels of this cytokine. Differential gene expression can be regulated from the selective action of transcriptional factors and also from epigenetic mechanisms, such as DNA CpG methylation or posttranslational histone modifications. Recently it has been recognized that epigenetic modification is an integral part of CD8 lymphocyte differentiation. This review will focus on the chromatin status of Ifng promoter in CD8 T cells and possible influences of epigenetic modifications in Ifng gene and conserved noncoding sequences (CNSs) in regulation of IFN-γ production by CD8 T lymphocytes. |
format | Online Article Text |
id | pubmed-4418004 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-44180042015-05-13 Epigenetic Control of Interferon-Gamma Expression in CD8 T Cells de Araújo-Souza, Patrícia S. Hanschke, Steffi C. H. Viola, João P. B. J Immunol Res Review Article Interferon- (IFN-) γ is an essential cytokine for immunity against intracellular pathogens and cancer. IFN-γ expression by CD4 T lymphocytes is observed only after T helper (Th) 1 differentiation and there are several studies about the molecular mechanisms that control Ifng expression in these cells. However, naïve CD8 T lymphocytes do not produce large amounts of IFN-γ, but after TCR stimulation there is a progressive acquisition of IFN-γ expression during differentiation into cytotoxic T lymphocytes (CTL) and memory cells, which are capable of producing high levels of this cytokine. Differential gene expression can be regulated from the selective action of transcriptional factors and also from epigenetic mechanisms, such as DNA CpG methylation or posttranslational histone modifications. Recently it has been recognized that epigenetic modification is an integral part of CD8 lymphocyte differentiation. This review will focus on the chromatin status of Ifng promoter in CD8 T cells and possible influences of epigenetic modifications in Ifng gene and conserved noncoding sequences (CNSs) in regulation of IFN-γ production by CD8 T lymphocytes. Hindawi Publishing Corporation 2015 2015-04-20 /pmc/articles/PMC4418004/ /pubmed/25973438 http://dx.doi.org/10.1155/2015/849573 Text en Copyright © 2015 Patrícia S. de Araújo-Souza et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article de Araújo-Souza, Patrícia S. Hanschke, Steffi C. H. Viola, João P. B. Epigenetic Control of Interferon-Gamma Expression in CD8 T Cells |
title | Epigenetic Control of Interferon-Gamma Expression in CD8 T Cells |
title_full | Epigenetic Control of Interferon-Gamma Expression in CD8 T Cells |
title_fullStr | Epigenetic Control of Interferon-Gamma Expression in CD8 T Cells |
title_full_unstemmed | Epigenetic Control of Interferon-Gamma Expression in CD8 T Cells |
title_short | Epigenetic Control of Interferon-Gamma Expression in CD8 T Cells |
title_sort | epigenetic control of interferon-gamma expression in cd8 t cells |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418004/ https://www.ncbi.nlm.nih.gov/pubmed/25973438 http://dx.doi.org/10.1155/2015/849573 |
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