Novel APC promoter and exon 1B deletion and allelic silencing in three mutation-negative classic familial adenomatous polyposis families

BACKGROUND: The overwhelming majority (approximately 80%) of individuals with classic familial adenomatous polyposis (FAP) exhibit mutations in the coding sequence of the adenomatous polyposis coli (APC) tumor suppressor gene. Families without detectable APC mutations are unable to benefit from the...

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Detalles Bibliográficos
Autores principales: Lin, Yiing, Lin, Shin, Baxter, Melanie D, Lin, Lawrence, Kennedy, Susan M, Zhang, Zhengyan, Goodfellow, Paul J, Chapman, William C, Davidson, Nicholas O
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418073/
https://www.ncbi.nlm.nih.gov/pubmed/25941542
http://dx.doi.org/10.1186/s13073-015-0148-0

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