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Fibrocalculous pancreatic diabetes: a case report

BACKGROUND: Diabetes is now becoming a major cause of morbidity and mortality in both developing and developed countries. Even though type 1 and type 2 are the commonest, diabetes mellitus due to secondary causes have been identified. Fibrocalculous Pancreatic Diabetes is a unique entity wherein pan...

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Autores principales: Ralapanawa, Dissanayake Mudiyanselage Priyantha Udaya Kumara, Jayawickreme, Kushalee Poornima, Ekanayake, Ekanayake Mudiyanselage Madhushanka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418105/
https://www.ncbi.nlm.nih.gov/pubmed/25924662
http://dx.doi.org/10.1186/s13104-015-1142-8
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author Ralapanawa, Dissanayake Mudiyanselage Priyantha Udaya Kumara
Jayawickreme, Kushalee Poornima
Ekanayake, Ekanayake Mudiyanselage Madhushanka
author_facet Ralapanawa, Dissanayake Mudiyanselage Priyantha Udaya Kumara
Jayawickreme, Kushalee Poornima
Ekanayake, Ekanayake Mudiyanselage Madhushanka
author_sort Ralapanawa, Dissanayake Mudiyanselage Priyantha Udaya Kumara
collection PubMed
description BACKGROUND: Diabetes is now becoming a major cause of morbidity and mortality in both developing and developed countries. Even though type 1 and type 2 are the commonest, diabetes mellitus due to secondary causes have been identified. Fibrocalculous Pancreatic Diabetes is a unique entity wherein pancreatic calcification and chronic inflammation lead to exocrine and endocrine failure of the pancreas. This form of non-alcoholic pancreatopathy is exclusively seen among the young, with a male preponderance and commonly in tropical countries where malnutrition and poverty go hand in hand. Whereas, interestingly this case has a late presentation in a female, unlike in other reported cases. For the best of our knowledge this is the first such documented case reported in Sri Lanka. CASE PRESENTATION: A 57 year old non-alcoholic Sinhalese female from Sri Lanka, presented with a history of chronic pancreatitis of nine years duration, after which she had developed severe Insulin Dependent Diabetes Mellitus. Imaging of the abdomen showed typical pancreatic calcifications, and this presentation accords with the criteria for Fibrocalculous pancreatic diabetes. CONCLUSION: This case report demonstrates a rare form of secondary diabetes in a middle aged female, without a childhood history of abdominal pain suggestive of pancreatitis, indicating late onset disease. Therefore a high index of suspicion is necessary even though the diagnostic criteria indicates the presence of childhood onset of disease.
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spelling pubmed-44181052015-05-05 Fibrocalculous pancreatic diabetes: a case report Ralapanawa, Dissanayake Mudiyanselage Priyantha Udaya Kumara Jayawickreme, Kushalee Poornima Ekanayake, Ekanayake Mudiyanselage Madhushanka BMC Res Notes Case Report BACKGROUND: Diabetes is now becoming a major cause of morbidity and mortality in both developing and developed countries. Even though type 1 and type 2 are the commonest, diabetes mellitus due to secondary causes have been identified. Fibrocalculous Pancreatic Diabetes is a unique entity wherein pancreatic calcification and chronic inflammation lead to exocrine and endocrine failure of the pancreas. This form of non-alcoholic pancreatopathy is exclusively seen among the young, with a male preponderance and commonly in tropical countries where malnutrition and poverty go hand in hand. Whereas, interestingly this case has a late presentation in a female, unlike in other reported cases. For the best of our knowledge this is the first such documented case reported in Sri Lanka. CASE PRESENTATION: A 57 year old non-alcoholic Sinhalese female from Sri Lanka, presented with a history of chronic pancreatitis of nine years duration, after which she had developed severe Insulin Dependent Diabetes Mellitus. Imaging of the abdomen showed typical pancreatic calcifications, and this presentation accords with the criteria for Fibrocalculous pancreatic diabetes. CONCLUSION: This case report demonstrates a rare form of secondary diabetes in a middle aged female, without a childhood history of abdominal pain suggestive of pancreatitis, indicating late onset disease. Therefore a high index of suspicion is necessary even though the diagnostic criteria indicates the presence of childhood onset of disease. BioMed Central 2015-04-30 /pmc/articles/PMC4418105/ /pubmed/25924662 http://dx.doi.org/10.1186/s13104-015-1142-8 Text en © Ralapanawa et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Ralapanawa, Dissanayake Mudiyanselage Priyantha Udaya Kumara
Jayawickreme, Kushalee Poornima
Ekanayake, Ekanayake Mudiyanselage Madhushanka
Fibrocalculous pancreatic diabetes: a case report
title Fibrocalculous pancreatic diabetes: a case report
title_full Fibrocalculous pancreatic diabetes: a case report
title_fullStr Fibrocalculous pancreatic diabetes: a case report
title_full_unstemmed Fibrocalculous pancreatic diabetes: a case report
title_short Fibrocalculous pancreatic diabetes: a case report
title_sort fibrocalculous pancreatic diabetes: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418105/
https://www.ncbi.nlm.nih.gov/pubmed/25924662
http://dx.doi.org/10.1186/s13104-015-1142-8
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