The role of necroptosis in neurosurgical diseases

Programmed necrosis or necroptosis is an alternative form of cell death that is executed through a caspase-independent pathway. Necroptosis has been implicated in many pathological conditions. Genetic or pharmacological inhibition of necroptotic signaling has been shown to confer neuroprotection aft...

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Autores principales: Liu, T., Bao, Y.H., Wang, Y., Jiang, J.Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Associação Brasileira de Divulgação Científica 2015
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418358/
https://www.ncbi.nlm.nih.gov/pubmed/25714887
http://dx.doi.org/10.1590/1414-431X20144310
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author Liu, T.
Bao, Y.H.
Wang, Y.
Jiang, J.Y.
author_facet Liu, T.
Bao, Y.H.
Wang, Y.
Jiang, J.Y.
author_sort Liu, T.
collection PubMed
description Programmed necrosis or necroptosis is an alternative form of cell death that is executed through a caspase-independent pathway. Necroptosis has been implicated in many pathological conditions. Genetic or pharmacological inhibition of necroptotic signaling has been shown to confer neuroprotection after traumatic and ischemic brain injury. Therefore, the necroptotic pathway represents a potential target for neurological diseases that are managed by neurosurgeons. In this review, we summarize recent advances in the understanding of necroptotic signaling pathways and explore the role of necroptotic cell death in craniocerebral trauma, brain tumors, and cerebrovascular diseases.
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spelling pubmed-44183582015-05-15 The role of necroptosis in neurosurgical diseases Liu, T. Bao, Y.H. Wang, Y. Jiang, J.Y. Braz J Med Biol Res Reviews Programmed necrosis or necroptosis is an alternative form of cell death that is executed through a caspase-independent pathway. Necroptosis has been implicated in many pathological conditions. Genetic or pharmacological inhibition of necroptotic signaling has been shown to confer neuroprotection after traumatic and ischemic brain injury. Therefore, the necroptotic pathway represents a potential target for neurological diseases that are managed by neurosurgeons. In this review, we summarize recent advances in the understanding of necroptotic signaling pathways and explore the role of necroptotic cell death in craniocerebral trauma, brain tumors, and cerebrovascular diseases. Associação Brasileira de Divulgação Científica 2015-02-24 /pmc/articles/PMC4418358/ /pubmed/25714887 http://dx.doi.org/10.1590/1414-431X20144310 Text en http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Liu, T.
Bao, Y.H.
Wang, Y.
Jiang, J.Y.
The role of necroptosis in neurosurgical diseases
title The role of necroptosis in neurosurgical diseases
title_full The role of necroptosis in neurosurgical diseases
title_fullStr The role of necroptosis in neurosurgical diseases
title_full_unstemmed The role of necroptosis in neurosurgical diseases
title_short The role of necroptosis in neurosurgical diseases
title_sort role of necroptosis in neurosurgical diseases
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418358/
https://www.ncbi.nlm.nih.gov/pubmed/25714887
http://dx.doi.org/10.1590/1414-431X20144310
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