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Novel Pactamycin Analogs Induce p53 Dependent Cell-Cycle Arrest at S-Phase in Human Head and Neck Squamous Cell Carcinoma (HNSCC) Cells

Pactamycin, although putatively touted as a potent antitumor agent, has never been used as an anticancer drug due to its high cytotoxicity. In this study, we characterized the effects of two novel biosynthetically engineered analogs of pactamycin, de-6MSA-7-demethyl-7-deoxypactamycin (TM-025) and 7-...

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Detalles Bibliográficos
Autores principales:	Guha, Gunjan, Lu, Wanli, Li, Shan, Liang, Xiaobo, Kulesz-Martin, Molly F., Mahmud, Taifo, Indra, Arup Kumar, Ganguli-Indra, Gitali
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418703/ https://www.ncbi.nlm.nih.gov/pubmed/25938491 http://dx.doi.org/10.1371/journal.pone.0125322

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