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Cardiovascular disease prediction: do pulmonary disease-related chest CT features have added value?
OBJECTIVE: Certain pulmonary diseases are associated with cardiovascular disease (CVD). Therefore we investigated the incremental predictive value of pulmonary, mediastinal and pleural features over cardiovascular imaging findings. METHODS: A total of 10,410 patients underwent diagnostic chest CT fo...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4419189/ https://www.ncbi.nlm.nih.gov/pubmed/25773934 http://dx.doi.org/10.1007/s00330-014-3495-0 |
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author | Jairam, Pushpa M. de Jong, Pim A. Mali, Willem P. Th. M. Isgum, Ivana van der Graaf, Yolanda |
author_facet | Jairam, Pushpa M. de Jong, Pim A. Mali, Willem P. Th. M. Isgum, Ivana van der Graaf, Yolanda |
author_sort | Jairam, Pushpa M. |
collection | PubMed |
description | OBJECTIVE: Certain pulmonary diseases are associated with cardiovascular disease (CVD). Therefore we investigated the incremental predictive value of pulmonary, mediastinal and pleural features over cardiovascular imaging findings. METHODS: A total of 10,410 patients underwent diagnostic chest CT for non-cardiovascular indications. Using a case-cohort approach, we visually graded CTs from the cases and from an approximately 10 % random sample of the baseline cohort (n = 1,203) for cardiovascular, pulmonary, mediastinal and pleural findings. The incremental value of pulmonary disease-related CT findings above cardiovascular imaging findings in cardiovascular event risk prediction was quantified by comparing discrimination and reclassification. RESULTS: During a mean follow-up of 3.7 years (max. 7.0 years), 1,148 CVD events (cases) were identified. Addition of pulmonary, mediastinal and pleural features to a cardiovascular imaging findings-based prediction model led to marginal improvement of discrimination (increase in c-index from 0.72 (95 % CI 0.71–0.74) to 0.74 (95 % CI 0.72–0.75)) and reclassification measures (net reclassification index 6.5 % (p < 0.01)). CONCLUSION: Pulmonary, mediastinal and pleural features have limited predictive value in the identification of subjects at high risk of CVD events beyond cardiovascular findings on diagnostic chest CT scans. KEY POINTS: • Incidental cardiovascular findings on routine chest CT can predict cardiovascular disease • Non-cardiovascular chest CT abnormalities are associated with cardiovascular disease • Non-cardiovascular chest CT features have limited predictive value beyond cardiovascular features ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00330-014-3495-0) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-4419189 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-44191892015-05-11 Cardiovascular disease prediction: do pulmonary disease-related chest CT features have added value? Jairam, Pushpa M. de Jong, Pim A. Mali, Willem P. Th. M. Isgum, Ivana van der Graaf, Yolanda Eur Radiol Computed Tomography OBJECTIVE: Certain pulmonary diseases are associated with cardiovascular disease (CVD). Therefore we investigated the incremental predictive value of pulmonary, mediastinal and pleural features over cardiovascular imaging findings. METHODS: A total of 10,410 patients underwent diagnostic chest CT for non-cardiovascular indications. Using a case-cohort approach, we visually graded CTs from the cases and from an approximately 10 % random sample of the baseline cohort (n = 1,203) for cardiovascular, pulmonary, mediastinal and pleural findings. The incremental value of pulmonary disease-related CT findings above cardiovascular imaging findings in cardiovascular event risk prediction was quantified by comparing discrimination and reclassification. RESULTS: During a mean follow-up of 3.7 years (max. 7.0 years), 1,148 CVD events (cases) were identified. Addition of pulmonary, mediastinal and pleural features to a cardiovascular imaging findings-based prediction model led to marginal improvement of discrimination (increase in c-index from 0.72 (95 % CI 0.71–0.74) to 0.74 (95 % CI 0.72–0.75)) and reclassification measures (net reclassification index 6.5 % (p < 0.01)). CONCLUSION: Pulmonary, mediastinal and pleural features have limited predictive value in the identification of subjects at high risk of CVD events beyond cardiovascular findings on diagnostic chest CT scans. KEY POINTS: • Incidental cardiovascular findings on routine chest CT can predict cardiovascular disease • Non-cardiovascular chest CT abnormalities are associated with cardiovascular disease • Non-cardiovascular chest CT features have limited predictive value beyond cardiovascular features ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00330-014-3495-0) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2015-03-14 2015 /pmc/articles/PMC4419189/ /pubmed/25773934 http://dx.doi.org/10.1007/s00330-014-3495-0 Text en © The Author(s) 2015 https://creativecommons.org/licenses/by-nc/4.0/ Open Access This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
spellingShingle | Computed Tomography Jairam, Pushpa M. de Jong, Pim A. Mali, Willem P. Th. M. Isgum, Ivana van der Graaf, Yolanda Cardiovascular disease prediction: do pulmonary disease-related chest CT features have added value? |
title | Cardiovascular disease prediction: do pulmonary disease-related chest CT features have added value? |
title_full | Cardiovascular disease prediction: do pulmonary disease-related chest CT features have added value? |
title_fullStr | Cardiovascular disease prediction: do pulmonary disease-related chest CT features have added value? |
title_full_unstemmed | Cardiovascular disease prediction: do pulmonary disease-related chest CT features have added value? |
title_short | Cardiovascular disease prediction: do pulmonary disease-related chest CT features have added value? |
title_sort | cardiovascular disease prediction: do pulmonary disease-related chest ct features have added value? |
topic | Computed Tomography |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4419189/ https://www.ncbi.nlm.nih.gov/pubmed/25773934 http://dx.doi.org/10.1007/s00330-014-3495-0 |
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