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Genetic Associations of PPARGC1A with Type 2 Diabetes: Differences among Populations with African Origins

The aim of this study was to assess the differences in correlation of PPARGC1A polymorphisms with type 2 diabetes (T2D) risk in adults of African origins: African Americans and Haitian Americans. The case-control study consisted of >30 years old, self-identified Haitian Americans (n = 110 cases a...

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Autores principales: Cheema, Amanpreet K., Li, Tan, Liuzzi, Juan P., Zarini, Gustavo G., Dorak, Mehmet T., Huffman, Fatma G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4419207/
https://www.ncbi.nlm.nih.gov/pubmed/25977930
http://dx.doi.org/10.1155/2015/921274
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author Cheema, Amanpreet K.
Li, Tan
Liuzzi, Juan P.
Zarini, Gustavo G.
Dorak, Mehmet T.
Huffman, Fatma G.
author_facet Cheema, Amanpreet K.
Li, Tan
Liuzzi, Juan P.
Zarini, Gustavo G.
Dorak, Mehmet T.
Huffman, Fatma G.
author_sort Cheema, Amanpreet K.
collection PubMed
description The aim of this study was to assess the differences in correlation of PPARGC1A polymorphisms with type 2 diabetes (T2D) risk in adults of African origins: African Americans and Haitian Americans. The case-control study consisted of >30 years old, self-identified Haitian Americans (n = 110 cases and n = 116 controls) and African Americans (n = 124 cases and n = 122 controls) living in South Florida with and without T2D. Adjusted logistic regression indicated that both SNP rs7656250 (OR = 0.22, P = 0.005) and rs4235308 (OR = 0.42, P = 0.026) showed protective association with T2D in Haitian Americans. In African Americans, however, rs4235308 showed significant risk association with T2D (OR = 2.53, P = 0.028). After stratification with sex, in Haitian Americans, both rs4235308 (OR = 0.38, P = 0.026) and rs7656250 (OR = 0.23, P = 0.006) showed protective association with T2D in females whereas in African American males rs7656250 had statistically significant protective effect on T2D (OR = 0.37, P = 0.043). The trends observed for genetic association of PPARGC1A SNPs, rs4235308, and rs7656250 for T2D between Haitian Americans and African Americans point out differences in Black race and warrant replicative study with larger sample size.
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spelling pubmed-44192072015-05-14 Genetic Associations of PPARGC1A with Type 2 Diabetes: Differences among Populations with African Origins Cheema, Amanpreet K. Li, Tan Liuzzi, Juan P. Zarini, Gustavo G. Dorak, Mehmet T. Huffman, Fatma G. J Diabetes Res Research Article The aim of this study was to assess the differences in correlation of PPARGC1A polymorphisms with type 2 diabetes (T2D) risk in adults of African origins: African Americans and Haitian Americans. The case-control study consisted of >30 years old, self-identified Haitian Americans (n = 110 cases and n = 116 controls) and African Americans (n = 124 cases and n = 122 controls) living in South Florida with and without T2D. Adjusted logistic regression indicated that both SNP rs7656250 (OR = 0.22, P = 0.005) and rs4235308 (OR = 0.42, P = 0.026) showed protective association with T2D in Haitian Americans. In African Americans, however, rs4235308 showed significant risk association with T2D (OR = 2.53, P = 0.028). After stratification with sex, in Haitian Americans, both rs4235308 (OR = 0.38, P = 0.026) and rs7656250 (OR = 0.23, P = 0.006) showed protective association with T2D in females whereas in African American males rs7656250 had statistically significant protective effect on T2D (OR = 0.37, P = 0.043). The trends observed for genetic association of PPARGC1A SNPs, rs4235308, and rs7656250 for T2D between Haitian Americans and African Americans point out differences in Black race and warrant replicative study with larger sample size. Hindawi Publishing Corporation 2015 2015-04-21 /pmc/articles/PMC4419207/ /pubmed/25977930 http://dx.doi.org/10.1155/2015/921274 Text en Copyright © 2015 Amanpreet K. Cheema et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Cheema, Amanpreet K.
Li, Tan
Liuzzi, Juan P.
Zarini, Gustavo G.
Dorak, Mehmet T.
Huffman, Fatma G.
Genetic Associations of PPARGC1A with Type 2 Diabetes: Differences among Populations with African Origins
title Genetic Associations of PPARGC1A with Type 2 Diabetes: Differences among Populations with African Origins
title_full Genetic Associations of PPARGC1A with Type 2 Diabetes: Differences among Populations with African Origins
title_fullStr Genetic Associations of PPARGC1A with Type 2 Diabetes: Differences among Populations with African Origins
title_full_unstemmed Genetic Associations of PPARGC1A with Type 2 Diabetes: Differences among Populations with African Origins
title_short Genetic Associations of PPARGC1A with Type 2 Diabetes: Differences among Populations with African Origins
title_sort genetic associations of ppargc1a with type 2 diabetes: differences among populations with african origins
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4419207/
https://www.ncbi.nlm.nih.gov/pubmed/25977930
http://dx.doi.org/10.1155/2015/921274
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