Cargando…

Chemokine-Ligands/Receptors: Multiplayers in Traumatic Spinal Cord Injury

Spinal cord injury (SCI) results in complex posttraumatic sequelae affecting the whole neuraxis. Due to its involvement in varied neuromodulatory processes, the chemokine-ligand/receptor-network is a key element of secondary lesion cascades induced by SCI. This review will provide a synopsis of chem...

Descripción completa

Detalles Bibliográficos
Autores principales: Knerlich-Lukoschus, Friederike, Held-Feindt, Janka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4419224/
https://www.ncbi.nlm.nih.gov/pubmed/25977600
http://dx.doi.org/10.1155/2015/486758
_version_ 1782369544847753216
author Knerlich-Lukoschus, Friederike
Held-Feindt, Janka
author_facet Knerlich-Lukoschus, Friederike
Held-Feindt, Janka
author_sort Knerlich-Lukoschus, Friederike
collection PubMed
description Spinal cord injury (SCI) results in complex posttraumatic sequelae affecting the whole neuraxis. Due to its involvement in varied neuromodulatory processes, the chemokine-ligand/receptor-network is a key element of secondary lesion cascades induced by SCI. This review will provide a synopsis of chemokine-ligand/receptor-expression along the whole neuraxis after traumatic spinal cord (sc) insults on basis of recent in vivo and in vitro findings in a SCI paradigm of thoracic force-defined impact lesions (Infinite Horizon Impactor) in adult rats. Analyses of chemokine-ligand/receptor-expression at defined time points after sc lesion of different severity grades or sham operation revealed that these inflammatory mediators are induced in distinct anatomical sc regions and in thalamic nuclei, periaqueductal grey, and hippocampal structures in the brain. Cellular and anatomical expression profiles together with colocalization/expression of neural stem/progenitor cell markers in adult sc stem cells niches or with pain-related receptors and mediators in dorsal horns, dorsal columns, and pain-processing brain areas support the notion that chemokines are involved in distinct cascades underlying clinical posttraumatic impairments and syndromes. These aspects and their implication in concepts of tailored SCI treatment are reviewed in the context of the recent literature on chemokine-ligand/receptor involvement in complex secondary lesion cascades.
format Online
Article
Text
id pubmed-4419224
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-44192242015-05-14 Chemokine-Ligands/Receptors: Multiplayers in Traumatic Spinal Cord Injury Knerlich-Lukoschus, Friederike Held-Feindt, Janka Mediators Inflamm Review Article Spinal cord injury (SCI) results in complex posttraumatic sequelae affecting the whole neuraxis. Due to its involvement in varied neuromodulatory processes, the chemokine-ligand/receptor-network is a key element of secondary lesion cascades induced by SCI. This review will provide a synopsis of chemokine-ligand/receptor-expression along the whole neuraxis after traumatic spinal cord (sc) insults on basis of recent in vivo and in vitro findings in a SCI paradigm of thoracic force-defined impact lesions (Infinite Horizon Impactor) in adult rats. Analyses of chemokine-ligand/receptor-expression at defined time points after sc lesion of different severity grades or sham operation revealed that these inflammatory mediators are induced in distinct anatomical sc regions and in thalamic nuclei, periaqueductal grey, and hippocampal structures in the brain. Cellular and anatomical expression profiles together with colocalization/expression of neural stem/progenitor cell markers in adult sc stem cells niches or with pain-related receptors and mediators in dorsal horns, dorsal columns, and pain-processing brain areas support the notion that chemokines are involved in distinct cascades underlying clinical posttraumatic impairments and syndromes. These aspects and their implication in concepts of tailored SCI treatment are reviewed in the context of the recent literature on chemokine-ligand/receptor involvement in complex secondary lesion cascades. Hindawi Publishing Corporation 2015 2015-04-21 /pmc/articles/PMC4419224/ /pubmed/25977600 http://dx.doi.org/10.1155/2015/486758 Text en Copyright © 2015 F. Knerlich-Lukoschus and J. Held-Feindt. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Knerlich-Lukoschus, Friederike
Held-Feindt, Janka
Chemokine-Ligands/Receptors: Multiplayers in Traumatic Spinal Cord Injury
title Chemokine-Ligands/Receptors: Multiplayers in Traumatic Spinal Cord Injury
title_full Chemokine-Ligands/Receptors: Multiplayers in Traumatic Spinal Cord Injury
title_fullStr Chemokine-Ligands/Receptors: Multiplayers in Traumatic Spinal Cord Injury
title_full_unstemmed Chemokine-Ligands/Receptors: Multiplayers in Traumatic Spinal Cord Injury
title_short Chemokine-Ligands/Receptors: Multiplayers in Traumatic Spinal Cord Injury
title_sort chemokine-ligands/receptors: multiplayers in traumatic spinal cord injury
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4419224/
https://www.ncbi.nlm.nih.gov/pubmed/25977600
http://dx.doi.org/10.1155/2015/486758
work_keys_str_mv AT knerlichlukoschusfriederike chemokineligandsreceptorsmultiplayersintraumaticspinalcordinjury
AT heldfeindtjanka chemokineligandsreceptorsmultiplayersintraumaticspinalcordinjury