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Functional Polymorphisms in COX-2 Gene Are Correlated with the Risk of Oral Cancer

Background. This meta-analysis investigated the association between functional COX-2 gene polymorphisms and the risk of oral cancer. Methods. Several electronic databases were searched for published studies using combinations of keywords related to COX-2 gene polymorphisms and oral cancer. After sel...

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Autores principales: Li, Dong, Hao, Shu-Hong, Sun, Yan, Hu, Chun-Mei, Ma, Zhi-Hua, Wang, Zhi Ming, Liu, Jie, Liu, Hong Bo, Ye, Ming, Zhang, Yu Fei, Yang, Dong Sheng, Shi, Guang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4419230/
https://www.ncbi.nlm.nih.gov/pubmed/25977924
http://dx.doi.org/10.1155/2015/580652
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author Li, Dong
Hao, Shu-Hong
Sun, Yan
Hu, Chun-Mei
Ma, Zhi-Hua
Wang, Zhi Ming
Liu, Jie
Liu, Hong Bo
Ye, Ming
Zhang, Yu Fei
Yang, Dong Sheng
Shi, Guang
author_facet Li, Dong
Hao, Shu-Hong
Sun, Yan
Hu, Chun-Mei
Ma, Zhi-Hua
Wang, Zhi Ming
Liu, Jie
Liu, Hong Bo
Ye, Ming
Zhang, Yu Fei
Yang, Dong Sheng
Shi, Guang
author_sort Li, Dong
collection PubMed
description Background. This meta-analysis investigated the association between functional COX-2 gene polymorphisms and the risk of oral cancer. Methods. Several electronic databases were searched for published studies using combinations of keywords related to COX-2 gene polymorphisms and oral cancer. After selection of relevant studies, following strict inclusion and exclusion criteria, data was performed using STATA 12.0 software. Results. We retrieved 83 studies from database search using specific search terms. After multiple rounds of selection and elimination, 7 studies were finally identified as suitable to be included in our present meta-analysis, based on their relevance and data integrity. These 7 studies contained a combined total of 2,296 oral cancer patients and 3,647 healthy controls. Our findings demonstrated that +837 T > C (rs5275) polymorphism in COX-2 showed statistically significant differences in gene frequencies in case and control groups in allele model and dominant model. Similar results were obtained with COX-2 gene polymorphism 765 G > C (rs20417). On the other hand, 1195 A > G (rs689466) polymorphism in COX-2 did not confer susceptibility to oral cancers. Conclusion. Based on our results, COX-2 gene polymorphisms, +837 T > C (rs5275) and −765G > C (rs20417), showed clear links with oral cancer susceptibility, and the 1195A > G (rs689466) polymorphism did not show such a correlation.
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spelling pubmed-44192302015-05-14 Functional Polymorphisms in COX-2 Gene Are Correlated with the Risk of Oral Cancer Li, Dong Hao, Shu-Hong Sun, Yan Hu, Chun-Mei Ma, Zhi-Hua Wang, Zhi Ming Liu, Jie Liu, Hong Bo Ye, Ming Zhang, Yu Fei Yang, Dong Sheng Shi, Guang Biomed Res Int Review Article Background. This meta-analysis investigated the association between functional COX-2 gene polymorphisms and the risk of oral cancer. Methods. Several electronic databases were searched for published studies using combinations of keywords related to COX-2 gene polymorphisms and oral cancer. After selection of relevant studies, following strict inclusion and exclusion criteria, data was performed using STATA 12.0 software. Results. We retrieved 83 studies from database search using specific search terms. After multiple rounds of selection and elimination, 7 studies were finally identified as suitable to be included in our present meta-analysis, based on their relevance and data integrity. These 7 studies contained a combined total of 2,296 oral cancer patients and 3,647 healthy controls. Our findings demonstrated that +837 T > C (rs5275) polymorphism in COX-2 showed statistically significant differences in gene frequencies in case and control groups in allele model and dominant model. Similar results were obtained with COX-2 gene polymorphism 765 G > C (rs20417). On the other hand, 1195 A > G (rs689466) polymorphism in COX-2 did not confer susceptibility to oral cancers. Conclusion. Based on our results, COX-2 gene polymorphisms, +837 T > C (rs5275) and −765G > C (rs20417), showed clear links with oral cancer susceptibility, and the 1195A > G (rs689466) polymorphism did not show such a correlation. Hindawi Publishing Corporation 2015 2015-04-21 /pmc/articles/PMC4419230/ /pubmed/25977924 http://dx.doi.org/10.1155/2015/580652 Text en Copyright © 2015 Dong Li et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Li, Dong
Hao, Shu-Hong
Sun, Yan
Hu, Chun-Mei
Ma, Zhi-Hua
Wang, Zhi Ming
Liu, Jie
Liu, Hong Bo
Ye, Ming
Zhang, Yu Fei
Yang, Dong Sheng
Shi, Guang
Functional Polymorphisms in COX-2 Gene Are Correlated with the Risk of Oral Cancer
title Functional Polymorphisms in COX-2 Gene Are Correlated with the Risk of Oral Cancer
title_full Functional Polymorphisms in COX-2 Gene Are Correlated with the Risk of Oral Cancer
title_fullStr Functional Polymorphisms in COX-2 Gene Are Correlated with the Risk of Oral Cancer
title_full_unstemmed Functional Polymorphisms in COX-2 Gene Are Correlated with the Risk of Oral Cancer
title_short Functional Polymorphisms in COX-2 Gene Are Correlated with the Risk of Oral Cancer
title_sort functional polymorphisms in cox-2 gene are correlated with the risk of oral cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4419230/
https://www.ncbi.nlm.nih.gov/pubmed/25977924
http://dx.doi.org/10.1155/2015/580652
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