The Role of α-Synuclein and LRRK2 in Tau Phosphorylation

There is now a considerable body of experimental evidence that Parkinson's disease arises through physiological interaction of causative molecules, leading to tau pathology. In this review, we discuss the physiological role of α-synuclein and LRRK2 in the abnormal phosphorylation of tau. In add...

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Detalles Bibliográficos
Autores principales: Kawakami, Fumitaka, Ichikawa, Takafumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4419261/
https://www.ncbi.nlm.nih.gov/pubmed/25977830
http://dx.doi.org/10.1155/2015/734746
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author Kawakami, Fumitaka
Ichikawa, Takafumi
author_facet Kawakami, Fumitaka
Ichikawa, Takafumi
author_sort Kawakami, Fumitaka
collection PubMed
description There is now a considerable body of experimental evidence that Parkinson's disease arises through physiological interaction of causative molecules, leading to tau pathology. In this review, we discuss the physiological role of α-synuclein and LRRK2 in the abnormal phosphorylation of tau. In addition, as recent reports have indicated that heat shock proteins- (HSPs-) inducing drugs can help to ameliorate neurodegenerative diseases associated with tau pathology, we also discuss therapeutic strategies for PD focusing on inhibition of α-synuclein- and LRRK2-associated tau phosphorylation by HSPs.
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spelling pubmed-44192612015-05-14 The Role of α-Synuclein and LRRK2 in Tau Phosphorylation Kawakami, Fumitaka Ichikawa, Takafumi Parkinsons Dis Review Article There is now a considerable body of experimental evidence that Parkinson's disease arises through physiological interaction of causative molecules, leading to tau pathology. In this review, we discuss the physiological role of α-synuclein and LRRK2 in the abnormal phosphorylation of tau. In addition, as recent reports have indicated that heat shock proteins- (HSPs-) inducing drugs can help to ameliorate neurodegenerative diseases associated with tau pathology, we also discuss therapeutic strategies for PD focusing on inhibition of α-synuclein- and LRRK2-associated tau phosphorylation by HSPs. Hindawi Publishing Corporation 2015 2015-04-21 /pmc/articles/PMC4419261/ /pubmed/25977830 http://dx.doi.org/10.1155/2015/734746 Text en Copyright © 2015 F. Kawakami and T. Ichikawa. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Kawakami, Fumitaka
Ichikawa, Takafumi
The Role of α-Synuclein and LRRK2 in Tau Phosphorylation
title The Role of α-Synuclein and LRRK2 in Tau Phosphorylation
title_full The Role of α-Synuclein and LRRK2 in Tau Phosphorylation
title_fullStr The Role of α-Synuclein and LRRK2 in Tau Phosphorylation
title_full_unstemmed The Role of α-Synuclein and LRRK2 in Tau Phosphorylation
title_short The Role of α-Synuclein and LRRK2 in Tau Phosphorylation
title_sort role of α-synuclein and lrrk2 in tau phosphorylation
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4419261/
https://www.ncbi.nlm.nih.gov/pubmed/25977830
http://dx.doi.org/10.1155/2015/734746
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