Cargando…
The Role of α-Synuclein and LRRK2 in Tau Phosphorylation
There is now a considerable body of experimental evidence that Parkinson's disease arises through physiological interaction of causative molecules, leading to tau pathology. In this review, we discuss the physiological role of α-synuclein and LRRK2 in the abnormal phosphorylation of tau. In add...
Autores principales: | Kawakami, Fumitaka, Ichikawa, Takafumi |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4419261/ https://www.ncbi.nlm.nih.gov/pubmed/25977830 http://dx.doi.org/10.1155/2015/734746 |
Ejemplares similares
-
LRRK2 Phosphorylates Tubulin-Associated Tau but Not the Free Molecule: LRRK2-Mediated Regulation of the Tau-Tubulin Association and Neurite Outgrowth
por: Kawakami, Fumitaka, et al.
Publicado: (2012) -
Phosphatases of α-synuclein, LRRK2, and tau: important players in the phosphorylation-dependent pathology of Parkinsonism
por: Taymans, Jean-Marc, et al.
Publicado: (2014) -
Leucine-rich repeat kinase 2 (LRRK2) regulates α-synuclein clearance in microglia
por: Maekawa, Tatsunori, et al.
Publicado: (2016) -
LRRK2 kinase regulates α-synuclein propagation via RAB35 phosphorylation
por: Bae, Eun-Jin, et al.
Publicado: (2018) -
LRRK2 phosphorylates novel tau epitopes and promotes tauopathy
por: Bailey, Rachel M., et al.
Publicado: (2013)