Specific bone cells produce DLL4 to generate thymus-seeding progenitors from bone marrow

Production of the cells that ultimately populate the thymus to generate α/β T cells has been controversial, and their molecular drivers remain undefined. Here, we report that specific deletion of bone-producing osteocalcin (Ocn)-expressing cells in vivo markedly reduces T-competent progenitors and t...

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Detalles Bibliográficos
Autores principales: Yu, Vionnie W.C., Saez, Borja, Cook, Colleen, Lotinun, Sutada, Pardo-Saganta, Ana, Wang, Ying-Hua, Lymperi, Stefania, Ferraro, Francesca, Raaijmakers, Marc H.G.P., Wu, Joy Y., Zhou, Lan, Rajagopal, Jayaraj, Kronenberg, Henry M., Baron, Roland, Scadden, David T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4419348/
https://www.ncbi.nlm.nih.gov/pubmed/25918341
http://dx.doi.org/10.1084/jem.20141843

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