An anti-silencer– and SATB1-dependent chromatin hub regulates Rag1 and Rag2 gene expression during thymocyte development

Rag1 and Rag2 gene expression in CD4(+)CD8(+) double-positive (DP) thymocytes depends on the activity of a distant anti-silencer element (ASE) that counteracts the activity of an intergenic silencer. However, the mechanistic basis for ASE activity is unknown. Here, we show that the ASE physically in...

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Detalles Bibliográficos
Autores principales: Hao, Bingtao, Naik, Abani Kanta, Watanabe, Akiko, Tanaka, Hirokazu, Chen, Liang, Richards, Hunter W., Kondo, Motonari, Taniuchi, Ichiro, Kohwi, Yoshinori, Kohwi-Shigematsu, Terumi, Krangel, Michael S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4419350/
https://www.ncbi.nlm.nih.gov/pubmed/25847946
http://dx.doi.org/10.1084/jem.20142207

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