DUSP4 deficiency caused by promoter hypermethylation drives JNK signaling and tumor cell survival in diffuse large B cell lymphoma

The epigenetic dysregulation of tumor suppressor genes is an important driver of human carcinogenesis. We have combined genome-wide DNA methylation analyses and gene expression profiling after pharmacological DNA demethylation with functional screening to identify novel tumor suppressors in diffuse...

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Detalles Bibliográficos
Autores principales: Schmid, Corina A., Robinson, Mark D., Scheifinger, Nicole A., Müller, Sebastian, Cogliatti, Sergio, Tzankov, Alexandar, Müller, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4419353/
https://www.ncbi.nlm.nih.gov/pubmed/25847947
http://dx.doi.org/10.1084/jem.20141957

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4419353/
https://www.ncbi.nlm.nih.gov/pubmed/25847947
http://dx.doi.org/10.1084/jem.20141957

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