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Biomechanical forces promote blood development through prostaglandin E(2) and the cAMP–PKA signaling axis

Blood flow promotes emergence of definitive hematopoietic stem cells (HSCs) in the developing embryo, yet the signals generated by hemodynamic forces that influence hematopoietic potential remain poorly defined. Here we show that fluid shear stress endows long-term multilineage engraftment potential...

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Detalles Bibliográficos
Autores principales:	Diaz, Miguel F., Li, Nan, Lee, Hyun Jung, Adamo, Luigi, Evans, Siobahn M., Willey, Hannah E., Arora, Natasha, Torisawa, Yu-suke, Vickers, Dwayne A., Morris, Samantha A., Naveiras, Olaia, Murthy, Shashi K., Ingber, Donald E., Daley, George Q., García-Cardeña, Guillermo, Wenzel, Pamela L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4419354/ https://www.ncbi.nlm.nih.gov/pubmed/25870199 http://dx.doi.org/10.1084/jem.20142235

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