The long non-coding RNA, GAS5, enhances gefitinib-induced cell death in innate EGFR tyrosine kinase inhibitor-resistant lung adenocarcinoma cells with wide-type EGFR via downregulation of the IGF-1R expression

BACKGROUND: Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are approved for patients with recurrent non-small cell lung cancer (NSCLC). However, the efficacy of EGFR-TKIs in NSCLC therapy is limited by primary and acquired resistance. Recent studies have revealed that long n...

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Detalles Bibliográficos
Autores principales: Dong, Siyuan, Qu, Xiaohan, Li, Wenya, Zhong, Xinwen, Li, Peiwen, Yang, Shize, Chen, Xitao, Shao, Mingrui, Zhang, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4419450/
https://www.ncbi.nlm.nih.gov/pubmed/25925741
http://dx.doi.org/10.1186/s13045-015-0140-6

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