Oroxylin A promotes PTEN-mediated negative regulation of MDM2 transcription via SIRT3-mediated deacetylation to stabilize p53 and inhibit glycolysis in wt-p53 cancer cells

INTRODUCTION: p53 plays important roles in regulating the metabolic reprogramming of cancer, such as aerobic glycolysis. Oroxylin A is a natural active flavonoid with strong anticancer effects both in vitro and in vivo. METHODS: wt-p53 (MCF-7 and HCT116 cells) cancer cells and p53-null H1299 cancer...

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Detalles Bibliográficos
Autores principales: Zhao, Kai, Zhou, Yuxin, Qiao, Chen, Ni, Ting, Li, Zhiyu, Wang, Xiaotang, Guo, Qinglong, Lu, Na, Wei, Libin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4419472/
https://www.ncbi.nlm.nih.gov/pubmed/25902914
http://dx.doi.org/10.1186/s13045-015-0137-1

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