Cargando…

Oxygen and glucose deprivation induces widespread alterations in mRNA translation within 20 minutes

BACKGROUND: Oxygen and glucose metabolism play pivotal roles in many (patho)physiological conditions. In particular, oxygen and glucose deprivation (OGD) during ischemia and stroke results in extensive tissue injury and cell death. RESULTS: Using time-resolved ribosome profiling, we assess gene expr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Andreev, Dmitry E, O’Connor, Patrick BF, Zhdanov, Alexander V, Dmitriev, Ruslan I, Shatsky, Ivan N, Papkovsky, Dmitri B, Baranov, Pavel V
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4419486/ https://www.ncbi.nlm.nih.gov/pubmed/25943107 http://dx.doi.org/10.1186/s13059-015-0651-z

Ejemplares similares

Translation initiation downstream from annotated start codons in human mRNAs coevolves with the Kozak context
por: Benitez-Cantos, Maria S., et al.
Publicado: (2020)

Bafilomycin A1 activates respiration of neuronal cells via uncoupling associated with flickering depolarization of mitochondria
por: Zhdanov, Alexander V., et al.
Publicado: (2010)

Bafilomycin A1 activates HIF-dependent signalling in human colon cancer cells via mitochondrial uncoupling
por: Zhdanov, Alexander V., et al.
Publicado: (2012)

Insights into the mechanisms of eukaryotic translation gained with ribosome profiling
por: Andreev, Dmitry E., et al.
Publicado: (2017)

Translation of 5′ leaders is pervasive in genes resistant to eIF2 repression
por: Andreev, Dmitry E, et al.
Publicado: (2015)

Comparative survey of the relative impact of mRNA features on local ribosome profiling read density
por: O'Connor, Patrick B. F., et al.
Publicado: (2016)

Optical probes and techniques for O(2) measurement in live cells and tissue
por: Dmitriev, Ruslan I., et al.
Publicado: (2012)

Ghrelin rapidly elevates protein synthesis in vitro by employing the rpS6K-eEF2K-eEF2 signalling axis
por: Zhdanov, Alexander V., et al.
Publicado: (2022)

Non-AUG translation initiation in mammals
por: Andreev, Dmitry E., et al.
Publicado: (2022)

A novel mechanism of eukaryotic translation initiation that is neither m(7)G-cap-, nor IRES-dependent
por: Terenin, Ilya M., et al.
Publicado: (2013)

Four translation initiation pathways employed by the leaderless mRNA in eukaryotes
por: Akulich, Kseniya A., et al.
Publicado: (2016)

Mitochondrial complex IV defects induce metabolic and signaling perturbations that expose potential vulnerabilities in HCT116 cells
por: Uchenunu, Oro, et al.
Publicado: (2022)

Use of Fluorescence Lifetime Imaging Microscopy (FLIM) as a Timer of Cell Cycle S Phase
por: Okkelman, Irina A., et al.
Publicado: (2016)

Glycyl-tRNA synthetase specifically binds to the poliovirus IRES to activate translation initiation
por: Andreev, Dmitri E., et al.
Publicado: (2012)

Differential contribution of the m(7)G-cap to the 5′ end-dependent translation initiation of mammalian mRNAs
por: Andreev, Dmitri E., et al.
Publicado: (2009)

Complexes of Ir(III)-Octaethylporphyrin with Peptides as Probes for Sensing Cellular O(2)
por: Koren, Klaus, et al.
Publicado: (2012)

A deeper understanding of intestinal organoid metabolism revealed by combining fluorescence lifetime imaging microscopy (FLIM) and extracellular flux analyses
por: Okkelman, Irina A., et al.
Publicado: (2019)

Translatome and transcriptome analysis of TMA20 (MCT-1) and TMA64 (eIF2D) knockout yeast strains
por: Makeeva, Desislava S., et al.
Publicado: (2019)

Systematic analysis of the PTEN 5′ leader identifies a major AUU initiated proteoform
por: Tzani, Ioanna, et al.
Publicado: (2016)

Analysis of tumour oxygenation in model animals on a phosphorescence lifetime based macro-imager
por: Zhdanov, Alexander V., et al.
Publicado: (2023)

Computational approach for calculating the probability of eukaryotic translation initiation from ribo-seq data that takes into account leaky scanning
por: Michel, Audrey M, et al.
Publicado: (2014)

In Vivo RNAi-Mediated eIF3m Knockdown Affects Ribosome Biogenesis and Transcription but Has Limited Impact on mRNA-Specific Translation
por: Smekalova, Elena M., et al.
Publicado: (2019)

Position dependent termination and widespread obligatory frameshifting in Euplotes translation
por: Lobanov, Alexei V., et al.
Publicado: (2016)

Sliding of a 43S ribosomal complex from the recognized AUG codon triggered by a delay in eIF2-bound GTP hydrolysis
por: Terenin, Ilya M., et al.
Publicado: (2016)

Reduced Oxidative Phosphorylation and Increased Glycolysis in Human Glaucoma Lamina Cribrosa Cells
por: Kamel, Khalid, et al.
Publicado: (2020)

rRNA:mRNA pairing alters the length and the symmetry of mRNA-protected fragments in ribosome profiling experiments
por: O’Connor, Patrick B. F., et al.
Publicado: (2013)

Elusive Trans-Acting Factors Which Operate with Type I (Poliovirus-like) IRES Elements
por: Andreev, Dmitry E., et al.
Publicado: (2022)

Polysomes Bypass a 50-Nucleotide Coding Gap Less Efficiently Than Monosomes Due to Attenuation of a 5′ mRNA Stem–Loop and Enhanced Drop-off
por: O'Loughlin, Sinéad, et al.
Publicado: (2020)

Unidirectional constant rate motion of the ribosomal scanning particle during eukaryotic translation initiation
por: Vassilenko, Konstantin S., et al.
Publicado: (2011)

Transcriptome sequencing suggests that pre-mRNA splicing counteracts widespread intronic cleavage and polyadenylation
por: Vlasenok, Maria, et al.
Publicado: (2023)

eIF4G2 balances its own mRNA translation via a PCBP2-based feedback loop
por: Smirnova, Victoria V., et al.
Publicado: (2019)

A widespread alternate form of cap-dependent mRNA translation initiation
por: de la Parra, Columba, et al.
Publicado: (2018)

Heterosubstituted Derivatives of PtPFPP for O(2) Sensing and Cell Analysis: Structure–Activity Relationships
por: Zanetti, Chiara, et al.
Publicado: (2022)

Steering surface topographies of electrospun fibers: understanding the mechanisms
por: Yazgan, Gökçe, et al.
Publicado: (2017)

TASEP modelling provides a parsimonious explanation for the ability of a single uORF to derepress translation during the integrated stress response
por: Andreev, Dmitry E, et al.
Publicado: (2018)

Evidence for widespread alterations in cortical microstructure after 32 h of sleep deprivation
por: Voldsbekk, Irene, et al.
Publicado: (2022)

Widespread Involvement of Acetylation in the Retinal Metabolism of Form-Deprivation Myopia in Guinea Pigs
por: Feng, Jiaojiao, et al.
Publicado: (2023)

Mapping O(2) concentration in ex-vivo tissue samples on a fast PLIM macro-imager
por: Sen, Rajannya, et al.
Publicado: (2020)

Widespread positive selection in the photosynthetic Rubisco enzyme
por: Kapralov, Maxim V, et al.
Publicado: (2007)

Operationalising the 20-minute neighbourhood
por: Thornton, Lukar E., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_uuu8mgu8l2nlupjg3376luqvtd